The average train between Orsay and Lyon takes 2h 23m and the fastest train takes 2h 17m. The train service runs several times per day from Orsay to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Orsay and Lyon. The earliest departure is at 7:01 AM in the morning, and the last departure from Orsay is at 7:12 PM which arrives into Lyon at 9:30 PM. All services require a transfer at Massy - Palaiseau and take an average of 2h 23m. The schedules shown below are for the next available departures.

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Want to know about travelling from Orsay to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Orsay to Lyon. However, there are services departing from Orsay station and arriving at Lyon station via Lyon Part Dieu. The journey, including transfers, takes approximately 2h 23m.
Orsay to Lyon train services, operated by Réseau Express Régional (RER Paris), depart from Massy Tgv station.
Orsay to Lyon train services, operated by Réseau Express Régional (RER Paris), arrive at Lyon Part Dieu station.
The distance between Orsay and Lyon is 384.3 km. The road distance is 440 km.
TGV inOui operates a train from Massy Tgv to Lyon Part Dieu every 4 hours. Tickets cost €90–150 and the journey takes 2h 4m. Société Nationale des Chemins de fer Français (SNCF) also services this route 3 times a day.