The average train between Orsay and Lyon takes 2h 22m and the fastest train takes 2h 17m. The train service runs several times per day from Orsay to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Orsay and Lyon. The earliest departure is at 7:05 AM in the morning, and the last departure from Orsay is at 7:12 PM which arrives into Lyon at 9:30 PM. All services require a transfer, and take on average 2h 22m. The schedules shown below are for the next available departures.

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2h 24m • 1 changeWant to know about travelling from Orsay to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Orsay to Lyon. However, there are services departing from Orsay station and arriving at Lyon station via Lyon Part Dieu. The journey, including transfers, takes approximately 2h 22m.
Orsay to Lyon train services, operated by Réseau Express Régional (RER Paris), depart from Massy - Palaiseau station.
Orsay to Lyon train services, operated by Réseau Express Régional (RER Paris), arrive at Lyon Part Dieu station.
The distance between Orsay and Lyon is 384.3 km. The road distance is 439 km.
TGV inOui operates a train from Massy - Palaiseau to Lyon Part Dieu hourly. Tickets cost €85–140 and the journey takes 2h 3m. Société Nationale des Chemins de fer Français (SNCF) also services this route every 4 hours.