The average bus between Orsay and Lyon takes 5h 50m and the fastest bus takes 5h 37m. The bus service runs several times per day from Orsay to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Orsay and Lyon. The earliest departure is at 7:22 PM in the evening, and the last departure from Orsay is at 11:32 PM which arrives into Lyon at 5:20 AM. All services require a transfer at Gare de Massy - Palaiseau and take an average of 5h 50m. The schedules shown below are for the next available departures.
Arrives next day

5h 47m • 1 change
Arrives next day

5h 57m • 1 change
Arrives next day

5h 37m • 1 change
Arrives next day

6h 3m • 1 change
Arrives next day

5h 37m • 1 change
Arrives next day

6h 3m • 1 change
Arrives next day

5h 37m • 1 change
Arrives next day

6h 3m • 1 change
Arrives next day

5h 37m • 1 change
Arrives next day

6h 3m • 1 change
Want to know about travelling from Orsay to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Orsay to Lyon. However, there are services departing from Orsay station and arriving at Lyon station via Lyon - Gerland Bus Station station. The journey, including transfers, takes approximately 5h 50m.
Orsay to Lyon bus services, operated by Paris-Saclay Mobilités, depart from Paris - Massy-Palaiseau Vilmorin Bus station.
Orsay to Lyon bus services, operated by Paris-Saclay Mobilités, arrive at Lyon - Gerland Bus Station.
The distance between Orsay and Lyon is 384.3 km. The road distance is 461 km.
BlaBlaCar Bus operates a bus from Paris - Massy-Palaiseau Vilmorin Bus to Lyon - Gerland Bus Station 3 times a day. Tickets cost €30–60 and the journey takes 5h 30m. FlixBus also services this route once daily.