The average train between Molsheim and Lyon takes 5h 14m and the fastest train takes 4h 13m. The train service runs several times per day from Molsheim to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Molsheim and Lyon. The earliest departure is at 5:44 AM in the morning, and the last departure from Molsheim is at 11:10 PM which arrives into Lyon at 10:59 AM. All services require a transfer, and take on average 5h 14m. The schedules shown below are for the next available departures.

4h 42m • 1 change

4h 43m • 1 change

5h 5m • 1 change

4h 39m • 1 change

5h 15m • 1 change

4h 15m • 1 change

4h 47m • 1 change

4h 18m • 1 change

4h 51m • 1 change

4h 45m • 1 change

4h 45m • 1 change

4h 40m • 1 change

4h 42m • 1 change

4h 43m • 1 change

4h 31m • 1 change

5h 5m • 1 change
Want to know about travelling from Molsheim to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Molsheim to Lyon. However, there are services departing from Molsheim station and arriving at Lyon station via Lyon Part Dieu. The journey, including transfers, takes approximately 5h 14m.
Molsheim to Lyon train services, operated by Société Nationale des Chemins de fer Français (SNCF), depart from Strasbourg station.
Molsheim to Lyon train services, operated by Société Nationale des Chemins de fer Français (SNCF), arrive at Lyon Part Dieu station.
Book your Molsheim to Lyon train tickets online with Société Nationale des Chemins de fer Français (SNCF) and TGV inOui.
The distance between Molsheim and Lyon is 369.4 km. The road distance is 523 km.
TGV inOui operates a train from Strasbourg to Lyon Part Dieu hourly. Tickets cost €110–180 and the journey takes 3h 58m.