The average train between Molsheim and Lyon takes 4h 41m and the fastest train takes 4h 13m. The train service runs several times per day from Molsheim to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Molsheim and Lyon. The earliest departure is at 6:17 AM in the morning, and the last departure from Molsheim is at 10:57 PM which arrives into Lyon at 10:59 AM. All services require a transfer, and take on average 4h 41m. The schedules shown below are for the next available departures.

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5h 5m • 1 changeWant to know about travelling from Molsheim to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Molsheim to Lyon. However, there are services departing from Molsheim station and arriving at Lyon station via Lyon Part Dieu. The journey, including transfers, takes approximately 4h 41m.
Molsheim to Lyon train services, operated by Société Nationale des Chemins de fer Français (SNCF), depart from Strasbourg station.
Molsheim to Lyon train services, operated by Société Nationale des Chemins de fer Français (SNCF), arrive at Lyon Part Dieu station.
Book your Molsheim to Lyon train tickets online with Société Nationale des Chemins de fer Français (SNCF) and TGV inOui.
The distance between Molsheim and Lyon is 369.4 km. The road distance is 517 km.
TGV inOui operates a train from Strasbourg to Lyon Part Dieu every 2 hours. Tickets cost €90–140 and the journey takes 3h 47m. Société Nationale des Chemins de fer Français (SNCF) also services this route twice daily.