The average train between Mannheim and Prague takes 9h 7m and the fastest train takes 8h 18m. The train service runs several times per day from Mannheim to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Mannheim and Prague. The earliest departure is at 4:01 AM at night, and the last departure from Mannheim is at 9:29 PM which arrives into Prague at 10:21 AM. All services require a transfer at Frankfurt and take an average of 9h 7m. The schedules shown below are for the next available departures.



8h 20m • 3 changes



8h 49m • 3 changes



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8h 18m • 3 changes
Want to know about travelling from Mannheim to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mannheim to Prague. However, there are services departing from Mannheim station and arriving at Prague station via Frankfurt. The journey, including transfers, takes approximately 9h 7m.
Mannheim to Prague train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mannheim, Hauptbahnhof station.
Mannheim to Prague train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Praha Hlavni Nadrazi station.
Book your Mannheim to Prague train tickets online with Deutsche Bahn Intercity (DB IC), Deutsche Bahn Regio (DB Regional) and Die Länderbahn.
The distance between Mannheim and Prague is 432.5 km. The road distance is 643 km.
You can take a train from Mannheim, Hauptbahnhof to Praha Hlavni Nadrazi via Frankfurt, Nürnberg Hbf, and Schwandorf in around 9h 15m.