The average train between Mannheim and Prague takes 9h 36m and the fastest train takes 7h 52m. The train service runs several times per day from Mannheim to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Mannheim and Prague. The earliest departure is at 2:15 AM at night, and the last departure from Mannheim is at 9:29 PM which arrives into Prague at 11:21 AM. All services require a transfer at Frankfurt and take an average of 9h 36m. The schedules shown below are for the next available departures.



11h 6m • 3 changes


7h 52m • 3 changes


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11h 6m • 3 changes


8h 18m • 3 changes


7h 52m • 3 changes


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11h 6m • 3 changes


8h 49m • 3 changes


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10h 6m • 3 changes


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10h 6m • 3 changes


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8h 18m • 3 changesWant to know about travelling from Mannheim to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mannheim to Prague. However, there are services departing from Mannheim, Hauptbahnhof station and arriving at Praha Hlavni Nadrazi station via Frankfurt station, Nürnberg Hbf station and Schwandorf station. The journey, including transfers, takes approximately 9h 36m.
Mannheim to Prague train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mannheim, Hauptbahnhof station.
Mannheim to Prague train services, operated by Die Länderbahn, arrive at Praha Hlavni Nadrazi station.
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The distance between Mannheim and Prague is 432.5 km. The road distance is 512 km.
You can take a train from Mannheim, Hauptbahnhof to Praha Hlavni Nadrazi via Frankfurt, Nürnberg Hbf, and Schwandorf in around 9h 5m.