The average train between Manchester and Iseo takes 24h 27m and the fastest train takes 22h 12m. There is at least one train per day from Manchester to Iseo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run once daily between Manchester and Iseo. The earliest departure is at 8:05 AM in the morning, and the last departure from Manchester is at 5:15 PM which arrives into Iseo at 4:27 PM. All services require a transfer at London Euston and take an average of 24h 27m. The schedules shown below are for the next available departures.
Arrives next day





23h 52m • 5 changes
Arrives next day





26h 53m • 5 changes
Arrives next day





23h 52m • 5 changes
Arrives next day





23h 12m • 5 changes
Want to know about travelling from Manchester to Iseo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Manchester to Iseo. However, there are services departing from Manchester station and arriving at Iseo station via London Euston. The journey, including transfers, takes approximately 24h 27m.
Manchester to Iseo train services, operated by Avanti West Coast, depart from Manchester Piccadilly station.
Manchester to Iseo train services, operated by Avanti West Coast, arrive at Brescia station.
Book your Manchester to Iseo train tickets online with Avanti West Coast, Eurostar and 4 other operators.
The distance between Manchester and Iseo is 1,238.4 km. The road distance is 1,757 km.
You can take a train from Manchester Piccadilly to Iseo via London Euston, London St Pancras Intl, Lille Europe, Lyon Part Dieu, Milano Centrale, and Brescia in around 15h 37m.