The average train between Manchester and Hamilton takes 3h 19m and the fastest train takes 2h 52m. There is a train service every few hours from Manchester to Hamilton. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Manchester and Hamilton. The earliest departure is at 6:36 AM in the morning, and the last departure from Manchester is at 11:36 PM which arrives into Hamilton at 6:55 AM. All services require a transfer, and take on average 3h 19m. The schedules shown below are for the next available departures.

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Arrives next day

7h 19m • 1 change

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2h 57m • 1 change

2h 53m • 1 change
Want to know about travelling from Manchester to Hamilton? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Manchester to Hamilton. However, there are services departing from Manchester station and arriving at Hamilton station via Preston. The journey, including transfers, takes approximately 3h 19m.
Manchester to Hamilton train services, operated by TransPennine Express, depart from Manchester Oxford Road station.
Manchester to Hamilton train services, operated by TransPennine Express, arrive at Motherwell station.
Book your Manchester to Hamilton train tickets online with TransPennine Express, Northern Trains Limited and 2 other operators.
The distance between Manchester and Hamilton is 279.2 km. The road distance is 336 km.
You can take a train from Manchester Oxford Road to Motherwell via Preston in around 3h 33m.