The average train between Manchester and Hamilton takes 3h 38m and the fastest train takes 2h 53m. There is a train service every few hours from Manchester to Hamilton. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run hourly between Manchester and Hamilton. The earliest departure is at 6:25 AM in the morning, and the last departure from Manchester is at 10:24 PM which arrives into Hamilton at 8:00 AM. All services require a transfer at Motherwell and take an average of 3h 38m. The schedules shown below are for the next available departures.

3h 51m • 1 change

3h 19m • 1 change

3h 28m • 1 change

2h 53m • 1 change

3h 51m • 1 change

3h 19m • 1 change

3h 28m • 1 change

2h 53m • 1 change

3h 51m • 1 change

3h 19m • 1 change

3h 28m • 1 change

2h 53m • 1 change

3h 51m • 1 change

3h 19m • 1 change

3h 28m • 1 change

2h 53m • 1 change
Want to know about travelling from Manchester to Hamilton? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Manchester to Hamilton. However, there are services departing from Manchester station and arriving at Hamilton station via Motherwell. The journey, including transfers, takes approximately 3h 38m.
Manchester to Hamilton train services, operated by TransPennine Express, depart from Manchester Piccadilly station.
Manchester to Hamilton train services, operated by TransPennine Express, arrive at Motherwell station.
Book your Manchester to Hamilton train tickets online with TransPennine Express, Northern Trains Limited and Avanti West Coast.
The distance between Manchester and Hamilton is 279.2 km. The road distance is 341 km.
TransPennine Express operates a train from Manchester Piccadilly to Motherwell every 4 hours. Tickets cost £75–130 and the journey takes 2h 59m.