The average train between Mainz and Zwickau takes 5h 57m and the fastest train takes 5h 32m. The train service runs several times per day from Mainz to Zwickau. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Mainz and Zwickau. The earliest departure is at 5:09 AM in the morning, and the last departure from Mainz is at 9:14 PM which arrives into Zwickau at 5:58 AM. All services require a transfer at Frankfurt and take an average of 5h 57m. The schedules shown below are for the next available departures.


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5h 41m • 2 changesWant to know about travelling from Mainz to Zwickau? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Zwickau. However, there are services departing from Mainz station and arriving at Zwickau station via Leipzig Hbf. The journey, including transfers, takes approximately 5h 57m.
Mainz to Zwickau train services, operated by vlexx, depart from Frankfurt station.
Mainz to Zwickau train services, operated by vlexx, arrive at Zwickau, Hauptbahnhof station.
Book your Mainz to Zwickau train tickets online with vlexx, Deutsche Bahn Intercity (DB IC) and Deutsche Bahn Regio (DB Regional).
The distance between Mainz and Zwickau is 309.8 km. The road distance is 494 km.
You can take a train from Mainz, Römisches Theater to Zwickau, Hauptbahnhof via Frankfurt and Leipzig Hbf in around 6h 9m.