The average train between Mainz and Wertheim takes 3h 25m and the fastest train takes 2h 54m. The train service runs several times per day from Mainz to Wertheim. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Mainz and Wertheim. The earliest departure is at 12:39 AM at night, and the last departure from Mainz is at 11:39 PM which arrives into Wertheim at 7:30 AM. All services require a transfer at Frankfurt(Main)Hbf and take an average of 3h 25m. The schedules shown below are for the next available departures.


3h 16m • 2 changes


2h 54m • 2 changes


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2h 54m • 2 changes


3h 16m • 2 changes


2h 54m • 2 changes


7h 54m • 2 changes


2h 54m • 2 changes


2h 54m • 2 changes


2h 54m • 2 changes


7h 54m • 2 changes


2h 54m • 2 changes


2h 54m • 2 changes


2h 54m • 2 changes


7h 54m • 2 changes


2h 54m • 2 changes


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2h 54m • 2 changes
Want to know about travelling from Mainz to Wertheim? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Wertheim. However, there are services departing from Mainz station and arriving at Wertheim station via Frankfurt(Main)Hbf. The journey, including transfers, takes approximately 3h 25m.
Mainz to Wertheim train services, operated by VIAS Rail GmbH, depart from Mainz-Kastel station.
Mainz to Wertheim train services, operated by VIAS Rail GmbH, arrive at Wertheim, Bahnhof station.
Book your Mainz to Wertheim train tickets online with VIAS Rail GmbH, Deutsche Bahn Regio (DB Regional) and Deutsche Bahn Intercity (DB IC).
The distance between Mainz and Wertheim is 91.6 km. The road distance is 146 km.
You can take a train from Mainz-Kastel to Wertheim, Bahnhof via Frankfurt(Main)Hbf, Frankfurt, and Aschaffenburg Hbf in around 3h 16m.