The average train between Mainz and Wertheim takes 3h 8m and the fastest train takes 2h 46m. The train service runs several times per day from Mainz to Wertheim. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Mainz and Wertheim. The earliest departure is at 4:04 AM at night, and the last departure from Mainz is at 8:14 PM which arrives into Wertheim at 11:15 PM. All services require a transfer at Frankfurt and take an average of 3h 8m. The schedules shown below are for the next available departures.


3h 21m • 2 changes


2h 59m • 2 changes


3h 21m • 2 changes


2h 59m • 2 changes


3h 26m • 2 changes


3h 21m • 2 changes


3h 18m • 2 changes


2h 46m • 2 changes


3h 26m • 2 changes


3h 21m • 2 changes


3h 18m • 2 changes


2h 46m • 2 changes


3h 29m • 2 changes


2h 59m • 2 changes


2h 59m • 2 changes


2h 59m • 2 changes
Want to know about travelling from Mainz to Wertheim? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Wertheim. However, there are services departing from Mainz station and arriving at Wertheim station via Frankfurt. The journey, including transfers, takes approximately 3h 8m.
Mainz to Wertheim train services, operated by Deutsche Bahn Regio (DB Regional), depart from Mainz, Römisches Theater station.
Mainz to Wertheim train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Wertheim, Bahnhof station.
Book your Mainz to Wertheim train tickets online with Deutsche Bahn Regio (DB Regional), Süwex and Deutsche Bahn Intercity (DB IC).
The distance between Mainz and Wertheim is 91.6 km. The road distance is 150 km.
You can take a train from Mainz, Römisches Theater to Wertheim, Bahnhof via Frankfurt and Aschaffenburg Hbf in around 3h 30m.