The average train between Cologne and Wertheim takes 3h 55m and the fastest train takes 3h 30m. The train service runs several times per day from Cologne to Wertheim. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 2 hours between Cologne and Wertheim. The earliest departure is at 5:20 AM in the morning, and the last departure from Cologne is at 7:45 PM which arrives into Wertheim at 11:15 PM. All services require a transfer, and take on average 3h 55m. The schedules shown below are for the next available departures.

3h 48m • 1 change

3h 48m • 1 change

3h 48m • 1 change

3h 48m • 1 change

4h 35m • 1 change

3h 48m • 1 change

4h 10m • 1 change

3h 48m • 1 change

4h 35m • 1 change

3h 48m • 1 change

4h 10m • 1 change

3h 48m • 1 change

4h 35m • 1 change

3h 48m • 1 change

4h 10m • 1 change

3h 48m • 1 change
Want to know about travelling from Cologne to Wertheim? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Cologne to Wertheim. However, there are services departing from Cologne station and arriving at Wertheim station via Aschaffenburg Hbf. The journey, including transfers, takes approximately 3h 55m.
Cologne to Wertheim train services, operated by Deutsche Bahn Intercity (DB IC), depart from Köln Messe/Deutz Bf station.
Cologne to Wertheim train services, operated by Deutsche Bahn Intercity (DB IC), arrive at Wertheim, Bahnhof station.
Book your Cologne to Wertheim train tickets online with Deutsche Bahn Intercity (DB IC) and Deutsche Bahn Regio (DB Regional).
The distance between Cologne and Wertheim is 223.6 km. The road distance is 291 km.
You can take a train from Köln Messe/Deutz Bf to Wertheim, Bahnhof via Aschaffenburg Hbf in around 3h 47m.