The average train between Mainz and Lille takes 7h 2m and the fastest train takes 5h 20m. The train service runs several times per day from Mainz to Lille. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Mainz and Lille. The earliest departure is at 5:05 AM in the morning, and the last departure from Mainz is at 7:14 PM which arrives into Lille at 7:12 AM. All services require a transfer at Frankfurt and take an average of 7h 2m. The schedules shown below are for the next available departures.


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5h 37m • 2 changes
Want to know about travelling from Mainz to Lille? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Lille. However, there are services departing from Mainz station and arriving at Lille station via Bruxelles Midi. The journey, including transfers, takes approximately 7h 2m.
Mainz to Lille train services, operated by vlexx, depart from Frankfurt station.
Mainz to Lille train services, operated by vlexx, arrive at Lille Europe station.
Book your Mainz to Lille train tickets online with vlexx, Deutsche Bahn Intercity (DB IC) and 3 other operators.
The distance between Mainz and Lille is 377.6 km. The road distance is 520 km.
You can take a train from Mainz, Römisches Theater to Lille Europe via Frankfurt, Bruxelles Midi, and Brussel-Zuid / Bruxelles-Midi in around 6h 33m.