The average train between Mainz and Brno takes 12h 27m and the fastest train takes 9h 58m. The train service runs several times per day from Mainz to Brno. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Mainz and Brno. The earliest departure is at 6:14 AM in the morning, and the last departure from Mainz is at 10:03 PM which arrives into Brno at 2:41 PM. All services require a transfer at Frankfurt and take an average of 12h 27m. The schedules shown below are for the next available departures.




9h 58m • 4 changes




10h 27m • 4 changes




11h 6m • 4 changes




11h 6m • 4 changes




9h 58m • 4 changes




10h 27m • 4 changes




11h 6m • 4 changes




11h 6m • 4 changes




9h 58m • 4 changes




10h 27m • 4 changes




11h 6m • 4 changes




11h 6m • 4 changes
Want to know about travelling from Mainz to Brno? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Brno. However, there are services departing from Mainz station and arriving at Brno station via München Hbf. The journey, including transfers, takes approximately 12h 27m.
Mainz to Brno train services, operated by Süwex, depart from Frankfurt station.
Mainz to Brno train services, operated by Süwex, arrive at Brno Hlavni Nadrazi station.
Book your Mainz to Brno train tickets online with Süwex, Deutsche Bahn Intercity (DB IC) and 9 other operators.
The distance between Mainz and Brno is 606.4 km. The road distance is 1,036 km.
You can take a train from Mainz, Römisches Theater to Brno Hlavni Nadrazi via Frankfurt, München Hbf, Salzburg Hauptbahnhof, Salzburg Hbf, and Wien Hbf in around 11h 27m.