The average train between Mainz and Brno takes 13h 11m and the fastest train takes 11h 27m. The train service runs several times per day from Mainz to Brno. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 4 times a day between Mainz and Brno. The earliest departure is at 12:34 AM at night, and the last departure from Mainz is at 11:14 PM which arrives into Brno at 2:41 PM. All services require a transfer at Frankfurt and take an average of 13h 11m. The schedules shown below are for the next available departures.




11h 37m • 4 changes




11h 27m • 4 changes
Arrives next day




16h 27m • 4 changes
Arrives next day




15h 27m • 4 changes




11h 36m • 4 changes




11h 36m • 4 changes
Arrives next day




16h 27m • 4 changes




12h 37m • 4 changes




11h 28m • 4 changes




11h 27m • 4 changes
Arrives next day




16h 27m • 4 changes




14h 7m • 4 changes




11h 28m • 4 changes




11h 27m • 4 changes
Arrives next day




16h 27m • 4 changes
Want to know about travelling from Mainz to Brno? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Brno. However, there are services departing from Mainz station and arriving at Brno station via München Hbf. The journey, including transfers, takes approximately 13h 11m.
Mainz to Brno train services, operated by vlexx, depart from Frankfurt station.
Mainz to Brno train services, operated by vlexx, arrive at Brno Hlavni Nadrazi station.
Book your Mainz to Brno train tickets online with vlexx, Deutsche Bahn Intercity (DB IC) and 6 other operators.
The distance between Mainz and Brno is 606.4 km. The road distance is 1,036 km.
You can take a train from Mainz, Römisches Theater to Brno Hlavni Nadrazi via Frankfurt, München Hbf, Muenchen Hbf, St.Poelten Hbf, and Wien Hbf in around 11h 3m.