The average train between Mainz and Brno takes 12h 35m and the fastest train takes 10h 20m. The train service runs several times per day from Mainz to Brno. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Mainz and Brno. The earliest departure is at 1:38 AM at night, and the last departure from Mainz is at 11:08 PM which arrives into Brno at 2:41 PM. All services require a transfer at Mannheim, Hauptbahnhof and take an average of 12h 35m. The schedules shown below are for the next available departures.




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10h 30m • 4 changesWant to know about travelling from Mainz to Brno? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Brno. However, there are services departing from Mainz, Hauptbahnhof station and arriving at Brno Hlavni Nadrazi station via Mannheim, Hauptbahnhof station, München Hbf station, Salzburg Hbf station and Wien Hbf station. The journey, including transfers, takes approximately 12h 35m.
Mainz to Brno train services, operated by Deutsche Bahn Intercity (DB IC), depart from Mainz, Hauptbahnhof station.
Mainz to Brno train services, operated by Railjet, arrive at Brno Hlavni Nadrazi station.
Book your Mainz to Brno train tickets online with Omio and 12go.asia.
The distance between Mainz and Brno is 606.4 km. The road distance is 744 km.
You can take a train from Mainz, Hauptbahnhof to Brno Hlavni Nadrazi via Mannheim, Hauptbahnhof, München Hbf, Muenchen Hbf Gl.5-10, Salzburg Hbf, and Wien Hbf in around 10h 16m.