The average train between Mainz and Brno takes 19h 7m and the fastest train takes 15h 7m. The train service runs several times per day from Mainz to Brno. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run 3 times a day between Mainz and Brno. The earliest departure is at 7:34 AM in the morning, and the last departure from Mainz is at 3:34 PM which arrives into Brno at 2:41 PM. All services require a transfer at Frankfurt and take an average of 19h 7m. The schedules shown below are for the next available departures.



15h 7m • 3 changes
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19h 7m • 3 changes
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23h 7m • 3 changes



15h 7m • 3 changes
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19h 7m • 3 changes
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23h 7m • 3 changes



15h 7m • 3 changes
Arrives next day



19h 7m • 3 changes
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23h 7m • 3 changes



15h 7m • 3 changes
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19h 7m • 3 changes
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23h 7m • 3 changes
Want to know about travelling from Mainz to Brno? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Brno. However, there are services departing from Mainz station and arriving at Brno station via Passau Hbf. The journey, including transfers, takes approximately 19h 7m.
Mainz to Brno train services, operated by Deutsche Bahn Regio (DB Regional), depart from Frankfurt station.
Mainz to Brno train services, operated by Deutsche Bahn Regio (DB Regional), arrive at Brno Hlavni Nadrazi station.
Book your Mainz to Brno train tickets online with Deutsche Bahn Regio (DB Regional), Deutsche Bahn Intercity (DB IC) and 2 other operators.
The distance between Mainz and Brno is 606.4 km. The road distance is 917 km.
You can take a train from Mainz, Römisches Theater to Brno Hlavni Nadrazi via Frankfurt, Passau Hbf, Wien Hauptbahnhof, and Wien Hbf in around 11h 30m.