The train between Mainz and Arnhem takes 3h 12m. There is at least one train per day from Mainz to Arnhem. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run once daily between Mainz and Arnhem. The earliest departure is at 5:09 AM in the morning, and the last departure from Mainz is at 7:14 PM which arrives into Arnhem at 10:26 PM. All services require a transfer, and take on average 3h 12m. The schedules shown below are for the next available departures.

3h 17m • 1 change

3h 13m • 1 change

3h 12m • 1 change

3h 12m • 1 change
Want to know about travelling from Mainz to Arnhem? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Mainz to Arnhem. However, there are services departing from Mainz station and arriving at Arnhem station via Arnhem Centraal. The journey, including transfers, takes approximately 3h 12m.
Mainz to Arnhem train services, operated by vlexx, depart from Frankfurt station.
Mainz to Arnhem train services, operated by vlexx, arrive at Arnhem Centraal station.
Book your Mainz to Arnhem train tickets online with vlexx and Deutsche Bahn Intercity (DB IC).
The distance between Mainz and Arnhem is 277 km. The road distance is 357 km.
Deutsche Bahn Intercity (DB IC) operates a train from Frankfurt to Arnhem Centraal every 3 hours. Tickets cost €60–240 and the journey takes 2h 40m. Nederlandse Spoorwegen (NS) also services this route every 3 hours.