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Lowell to Buffalo trains

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Trip Overview

The train between Lowell and Buffalo takes 28h 18m. The train runs, on average, 6 times per week from Lowell to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

28h 18m
Duration
523 mi
Distance
$367
Average price
6 times a week
Frequency

Lowell to Buffalo train times

Trains run 6 times a week between Lowell and Buffalo. The earliest departure is at 11:22 AM in the morning, and the last departure from Lowell is at 11:22 AM which arrives into Buffalo at 3:40 PM. All services require a transfer at North Station and take an average of 28h 18m. The schedules shown below are for the next available departures.

Departing Monday, October 19, 2026

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    MBTAMBTAAmtrakAmtrak28h 18m • 3 changes

Departing Tuesday, October 20, 2026

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    Arrives next day

    MBTAMBTAAmtrakAmtrak28h 18m • 3 changes

Departing Wednesday, October 21, 2026

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    Arrives next day

    MBTAMBTAAmtrakAmtrak28h 18m • 3 changes

Departing Thursday, October 22, 2026

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    Arrives next day

    MBTAMBTAAmtrakAmtrak28h 18m • 3 changes

Departing Friday, October 23, 2026

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    Arrives next day

    MBTAMBTAAmtrakAmtrak28h 18m • 3 changes

Departing Saturday, October 24, 2026

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    Arrives next day

    MBTAMBTAAmtrakAmtrak28h 18m • 3 changes

Frequently asked questions

Want to know about travelling from Lowell to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Lowell to Buffalo.ExpandLaunch map view
  • Distance: 522.5 mi
  • Duration: 28h 18m

What companies run services between Lowell, MA, USA and Buffalo, NY, USA?

You can take a train from Lowell to Buffalo via North Station, North Station, Back Bay, Boston, and Buffalo Depew Station in around 14h 50m.

Operators