Rome2Rio

Lowell to Buffalo trains

Find Transport to Buffalo

View schedule

Trip Overview

The train between Lowell and Buffalo takes 28h 8m. The train runs, on average, 6 times per week from Lowell to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

28h 8m
Duration
523 mi
Distance
$367
Average price
6 times a week
Frequency

Lowell to Buffalo train times

Trains run 6 times a week between Lowell and Buffalo. The service departs Lowell at 11:22 AM in the morning, which arrives into Buffalo at 15:30:00. All services require a transfer at North Station and take an average of 28h 8m. The schedules shown below are for the next available departures.

Departing Sunday, November 8, 2026

  •  → 

    Arrives next day

    MBTAMBTAAmtrakVIA Rail28h 8m • 3 changes

Departing Monday, November 9, 2026

  •  → 

    Arrives next day

    MBTAMBTAAmtrakVIA Rail28h 8m • 3 changes

Departing Tuesday, November 10, 2026

  •  → 

    Arrives next day

    MBTAMBTAAmtrakVIA Rail28h 8m • 3 changes

Departing Wednesday, November 11, 2026

  •  → 

    Arrives next day

    MBTAMBTAAmtrakVIA Rail28h 8m • 3 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives next day

    MBTAMBTAAmtrakVIA Rail28h 8m • 3 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives next day

    MBTAMBTAAmtrakVIA Rail28h 8m • 3 changes

Frequently asked questions

Want to know about travelling from Lowell to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Lowell to Buffalo.ExpandLaunch map view
  • Distance: 522.5 mi
  • Duration: 28h 8m

What companies run services between Lowell, MA, USA and Buffalo, NY, USA?

You can take a train from Lowell to Buffalo via North Station, North Station, Back Bay, Boston, and Buffalo Depew Station in around 14h 50m.

Operators