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How to get fromLowell to Buffaloby train, plane, bus (Greyhound, Flixbus), train (Amtrak), car or bus

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There are 6 ways to get from Lowell to Buffalo by train, plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, fly to Buffalo Niagara International Airport

    best
    1. Take the train from Lowell to Anderson/Woburntrain
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)planeBOS - BUF
    5h 9m
    $166–1,047
  2. Train, bus

    cheapest
    1. Take the train from Lowell to North Stationtrain
    2. Take the bus from Boston, MA to Syracuse, NYbus
    3. Take the bus from Syracuse, NY to Buffalo, NYbus
    13h 17m
    $49–170
  3. Bus

    1. Take the bus from Robert B Kennedy Bus Transfer Center to Bostonbus
    2. Take the bus from Boston to Syracuse Bus Stationbus
    3. Take the bus from Syracuse Bus Station to Buffalobus
    12h 3m
    $79–187
  4. Train

    1. Take the train from Lowell to North StationtrainLowell Line
    2. Take the train from Boston to Buffalo Depew StationtrainLake Shore Limited
    14h 50m
    $66–258
  5. Drive 435 mi

    1. Drive from Lowell to Buffalocar435 mi
    8h 39m
    $80–115
  6. Fly to Rochester, bus

    1. Fly from Boston Logan Airport (BOS) to Rochester (ROC)planeBOS - ROC
    2. Take the bus from Rochester, NY to Buffalo, NYbus
    7h 8m
    $226–652

Lowell to Buffalo by bus

Calendar5Weekly Buses
Duration12h 3mAverage Duration
Ticket$79Cheapest Price
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Questions & Answers

What companies run services between Lowell, MA, USA and Buffalo, NY, USA?

You can take a bus from Robert B Kennedy Bus Transfer Center to Buffalo via Boston and Syracuse Bus Station in around 12h 3m. Alternatively, you can take a train from Lowell to Buffalo via North Station, North Station, Back Bay, Boston, and Buffalo Depew Station in around 14h 50m.

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