There are 6 ways to get from Lowell to Buffalo by train, plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train, fly to Buffalo Niagara International Airport
best- Take the train from Lowell to Anderson/Woburn
- Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)BOS - BUF
5h 9m$166–1,047Train, bus
cheapest- Take the train from Lowell to North Station
- Take the bus from Boston, MA to Syracuse, NY
- Take the bus from Syracuse, NY to Buffalo, NY
13h 17m$49–170Bus
- Take the bus from Robert B Kennedy Bus Transfer Center to Boston
- Take the bus from Boston to Syracuse Bus Station
- Take the bus from Syracuse Bus Station to Buffalo
12h 3m$79–187Train
- Take the train from Lowell to North StationLowell Line
- Take the train from Boston to Buffalo Depew StationLake Shore Limited
14h 50m$66–258Drive 435 mi
- Drive from Lowell to Buffalo435 mi
8h 39m$80–115Fly to Rochester, bus
- Fly from Boston Logan Airport (BOS) to Rochester (ROC)BOS - ROC
- Take the bus from Rochester, NY to Buffalo, NY
7h 8m$226–652
Lowell to Buffalo by bus
Questions & Answers
The cheapest way to get from Lowell to Buffalo is to train and bus which costs $45 - $170 and takes 13h 17m.
The fastest way to get from Lowell to Buffalo is to train and fly which takes 5h 9m and costs $160 - $1,100.
No, there is no direct bus from Lowell to Buffalo. However, there are services departing from Robert B Kennedy Bus Transfer Center and arriving at Buffalo via Boston and Syracuse Bus Station. The journey, including transfers, takes approximately 12h 3m.
No, there is no direct train from Lowell to Buffalo. However, there are services departing from Lowell and arriving at Buffalo via North Station, Boston and Buffalo Depew Station. The journey, including transfers, takes approximately 14h 50m.
The distance between Lowell and Buffalo is 435 miles. The road distance is 437.5 miles.
The best way to get from Lowell to Buffalo without a car is to bus which takes 12h 3m and costs $75 - $190.
It takes approximately 5h 9m to get from Lowell to Buffalo, including transfers.
Lowell to Buffalo bus services, operated by Greyhound USA, depart from Robert B Kennedy Bus Transfer Center station.
Lowell to Buffalo train services, operated by MBTA, depart from Lowell station.
The best way to get from Lowell to Buffalo is to bus which takes 12h 3m and costs $75 - $190. Alternatively, you can train, which costs $65 - $260 and takes 14h 50m.
What companies run services between Lowell, MA, USA and Buffalo, NY, USA?
You can take a bus from Robert B Kennedy Bus Transfer Center to Buffalo via Boston and Syracuse Bus Station in around 12h 3m. Alternatively, you can take a train from Lowell to Buffalo via North Station, North Station, Back Bay, Boston, and Buffalo Depew Station in around 14h 50m.
- Website
- aa.com
Flights from Boston Logan Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 47m
- When
- Sunday
- Estimated price
- $150–950
Flights from Boston Logan Airport to Buffalo Niagara International Airport via Reagan Washington
- Ave. Duration
- 4h 8m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $200–1,200
Flights from Boston Logan Airport to Rochester
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- $75–470
Flights from Boston Logan Airport to Rochester via Philadelphia
- Ave. Duration
- 4h 6m
- When
- Every day
- Estimated price
- $90–550
- Website
- southwest.com
Flights from Boston Logan Airport to Buffalo Niagara International Airport via Baltimore
- Ave. Duration
- 3h 52m
- When
- Every day
- Estimated price
- $190–1,100
Flights from Boston Logan Airport to Rochester via Baltimore
- Ave. Duration
- 4h 1m
- When
- Monday, Friday, and Saturday
- Estimated price
- $100–600
- Website
- delta.com
Flights from Boston Logan Airport to Buffalo Niagara International Airport via New York La Guardia
- Ave. Duration
- 3h 54m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $170–1,000
Flights from Boston Logan Airport to Rochester via New York La Guardia
- Ave. Duration
- 3h 57m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $80–500
Flights from Boston Logan Airport to Rochester via New York JFK
- Ave. Duration
- 4h 3m
- When
- Monday to Wednesday
- Estimated price
- $85–500
- Website
- jetblue.com
Flights from Boston Logan Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 42m
- When
- Every day
- Estimated price
- $150–950
Flights from Boston Logan Airport to Buffalo Niagara International Airport via New York JFK
- Ave. Duration
- 3h 59m
- When
- Every day
- Estimated price
- $170–1,000
Flights from Boston Logan Airport to Rochester via New York JFK
- Ave. Duration
- 3h 48m
- When
- Every day
- Estimated price
- $85–500
- Website
- united.com
Flights from Boston Logan Airport to Buffalo Niagara International Airport via Newark
- Ave. Duration
- 4h 4m
- When
- Every day
- Estimated price
- $170–1,000
Flights from Boston Logan Airport to Rochester via Newark
- Ave. Duration
- 4h 1m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $80–500
- Phone
- +1-617-222-3200
- Website
- mbta.com
Train from Lowell to Anderson/Woburn
- Ave. Duration
- 19 min
- Frequency
- Hourly
- Estimated price
- $3–8
- Website
- https://www.mbta.com
- Adult
- $3–8
Train from Lowell to North Station
- Ave. Duration
- 45 min
- Frequency
- Hourly
- Estimated price
- $4–11
- Website
- https://www.mbta.com
- Adult
- $4–11
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Boston to Buffalo Depew Station
- Ave. Duration
- 11h 32m
- Frequency
- Once daily
- Estimated price
- $50–170
- Website
- https://www.amtrak.com/home.html
- Coach Seat - Advance Purchase
- $50–120
- Coach Seat short notice purchase
- $60–170
- Business - advance purchase
- $85–360
- Business Class
- $140–390
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Robert B Kennedy Bus Transfer Center to Boston
- Ave. Duration
- 45 min
- Frequency
- 5 times a week
- Estimated price
- $9–13
- Website
- https://www.greyhound.com/
Bus from Boston to Syracuse Bus Station
- Ave. Duration
- 6h 40m
- Frequency
- Once daily
- Estimated price
- $45–130
- Website
- https://www.greyhound.com/
Bus from Syracuse Bus Station to Buffalo
- Ave. Duration
- 3h 20m
- Frequency
- 4 times a day
- Estimated price
- $27–45
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Boston to Syracuse Bus Station
- Ave. Duration
- 6h 35m
- Frequency
- 6 times a week
- Estimated price
- $45–120
- Schedules at
- flixbus.com
Bus from Syracuse Bus Station to Buffalo
- Ave. Duration
- 2h 55m
- Frequency
- Every 4 hours
- Estimated price
- $27–40
- Schedules at
- flixbus.com
- Phone
- +1 800-858-8555
- Website
- trailways.com
Bus from Syracuse Bus Station to Buffalo
- Ave. Duration
- 3h 10m
- Frequency
- 4 times a day
- Estimated price
- $25–40
- Website
- https://trailways.com
- Schedules at
- https://trailways.com/schedules/
- Phone
- +1-844-800-6828
- pr@ourbus.com
- Website
- ourbus.com
Bus from Rochester, NY to Buffalo, NY
- Ave. Duration
- 1h
- Frequency
- Once daily
- Estimated price
- $20–55
- Website
- https://www.ourbus.com
Bus from Boston, MA to Syracuse, NY
- Ave. Duration
- 6h 25m
- Frequency
- Twice a week
- Estimated price
- $20–90
- Website
- https://www.ourbus.com
Bus from Syracuse, NY to Buffalo, NY
- Ave. Duration
- 2h 45m
- Frequency
- 4 times a week
- Estimated price
- $20–65
- Website
- https://www.ourbus.com
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More Questions & Answers
Lowell to Buffalo bus services, operated by Greyhound USA, arrive at Boston station.
Lowell to Buffalo train services, operated by MBTA, arrive at North Station.
Yes, the driving distance between Lowell to Buffalo is 438 miles. It takes approximately 8h 39m to drive from Lowell to Buffalo.
Book your Lowell to Buffalo bus tickets online with Omio and FlixBus.
There are 217+ hotels available in Buffalo.
















