The average train between Derby and Prestwick takes 6h 43m and the fastest train takes 5h 48m. The train service runs several times per day from Derby to Prestwick. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 4 hours between Derby and Prestwick. The earliest departure is at 6:24 AM in the morning, and the last departure from Derby is at 9:48 PM which arrives into Prestwick at 10:15 AM. All services require a transfer at Crewe and take an average of 6h 43m. The schedules shown below are for the next available departures.


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Want to know about travelling from Derby to Prestwick? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Derby to Prestwick. However, there are services departing from Derby station and arriving at Prestwick station via Crewe. The journey, including transfers, takes approximately 6h 43m.
Derby to Prestwick train services, operated by East Midlands Railways, depart from Derby station.
Derby to Prestwick train services, operated by East Midlands Railways, arrive at Prestwick Town station.
Book your Derby to Prestwick train tickets online with East Midlands Railways, Avanti West Coast and ScotRail.
The distance between Derby and Prestwick is 351.4 km. The road distance is 530 km.
You can take a train from Derby to Prestwick Town via Crewe and Glasgow Central in around 6h 30m.