The average train between Amsterdam and Melsele takes 2h 20m and the fastest train takes 2h 5m. The train service runs several times per day from Amsterdam to Melsele. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Trains run every 3 hours between Amsterdam and Melsele. The earliest departure is at 5:40 AM in the morning, and the last departure from Amsterdam is at 9:10 PM which arrives into Melsele at 11:15 PM. All services require a transfer, and take on average 2h 20m. The schedules shown below are for the next available departures.

2h 5m • 1 change

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2h 34m • 1 change

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2h 34m • 1 change

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2h 5m • 1 change

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2h 5m • 1 change
Want to know about travelling from Amsterdam to Melsele? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct train from Amsterdam to Melsele. However, there are services departing from Amsterdam station and arriving at Melsele station via Anvers-Central. The journey, including transfers, takes approximately 2h 20m.
Amsterdam to Melsele train services, operated by Eurostar, depart from Amsterdam Centraal station.
Amsterdam to Melsele train services, operated by Eurostar, arrive at Melsele station.
Book your Amsterdam to Melsele train tickets online with Eurostar, Belgian Railways (NMBS/SNCB) and Nederlandse Spoorwegen (NS).
The distance between Amsterdam and Melsele is 134.8 km. The road distance is 173 km.
You can take a train from Amsterdam Centraal to Melsele via Anvers-Central in around 2h 11m.