The average bus between Vesoul and Lyon takes 5h 37m and the fastest bus takes 4h 50m. The bus service runs several times per day from Vesoul to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Vesoul and Lyon. The earliest departure is at 7:30 AM in the morning, and the last departure from Vesoul is at 7:15 PM which arrives into Lyon at 1:25 AM. All services require a transfer, and take on average 5h 37m. The schedules shown below are for the next available departures.

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Want to know about travelling from Vesoul to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Vesoul to Lyon. However, there are services departing from Vesoul station and arriving at Lyon station via PEM Viotte. The journey, including transfers, takes approximately 5h 37m.
Vesoul to Lyon bus services, operated by Mobigo - Doubs, depart from Pôle Multimodal station.
Vesoul to Lyon bus services, operated by Mobigo - Doubs, arrive at Lyon station.
Book your Vesoul to Lyon bus tickets online with Mobigo - Doubs and FlixBus.
The distance between Vesoul and Lyon is 231 km. The road distance is 274 km.
You can take a bus from Pôle Multimodal to Lyon via Besançon in around 4h 37m.