The average bus between Vesoul and Lyon takes 5h 51m and the fastest bus takes 4h. The bus service runs several times per day from Vesoul to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Vesoul and Lyon. The earliest departure is at 7:30 AM in the morning, and the last departure from Vesoul is at 9:46 PM which arrives into Lyon at 12:40 PM. All services require a transfer, and take on average 5h 51m. The schedules shown below are for the next available departures.

5h 10m • 1 change

4h • 1 change

6h 10m • 1 change

5h 20m • 1 change

4h 50m • 1 change

4h • 1 change

6h 10m • 1 change

4h 55m • 1 change

4h 50m • 1 change

4h • 1 change

6h 10m • 1 change

4h 55m • 1 change
Want to know about travelling from Vesoul to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Vesoul to Lyon. However, there are services departing from Vesoul station and arriving at Lyon station via PEM Viotte. The journey, including transfers, takes approximately 5h 51m.
Vesoul to Lyon bus services, operated by Mobigo - Doubs, depart from Pôle Multimodal station.
Vesoul to Lyon bus services, operated by Mobigo - Doubs, arrive at Lyon station.
The distance between Vesoul and Lyon is 231 km. The road distance is 274 km.
You can take a bus from Pôle Multimodal to Lyon via Besançon in around 4h 37m.