The average bus between Strasbourg and Main takes 6h 20m and the fastest bus takes 5h 2m. The bus service runs several times per day from Strasbourg to Main. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Strasbourg and Main. The earliest departure is at 3:30 AM at night, and the last departure from Strasbourg is at 8:35 PM which arrives into Main at 6:57 AM. All services require a transfer at Frankfurt Airport and take an average of 6h 20m. The schedules shown below are for the next available departures.


7h 27m • 2 changes


5h 37m • 2 changes


5h 57m • 2 changes


5h 32m • 2 changes


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5h 2m • 2 changes


7h 27m • 2 changes


5h 37m • 2 changes


5h 57m • 2 changes


5h 32m • 2 changes


7h 27m • 2 changes


5h 37m • 2 changes


5h 57m • 2 changes


5h 32m • 2 changes


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5h 37m • 2 changes


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5h 32m • 2 changes
Want to know about travelling from Strasbourg to Main? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Strasbourg to Main. However, there are services departing from Strasbourg station and arriving at Main station via Frankfurt Airport. The journey, including transfers, takes approximately 6h 20m.
Strasbourg to Main bus services, operated by FlixBus, depart from Strasbourg station.
Strasbourg to Main bus services, operated by FlixBus, arrive at Frankfurt Airport station.
The distance between Strasbourg and Main is 161.8 km. The road distance is 261 km.
FlixBus operates a bus from Strasbourg to Frankfurt Airport every 4 hours. Tickets cost €17–29 and the journey takes 3h 35m. BlaBlaCar Bus also services this route every 4 hours.