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St. Louis to Santa Ana buses

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Trip Overview

The bus between St. Louis and Santa Ana takes 44h 55m. The bus runs, on average, 5 times per week from St. Louis to Santa Ana. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

44h 55m
Duration
1,946 mi
Distance
$423
Average price
5 times a week
Frequency

St. Louis to Santa Ana bus times

Buses run 5 times a week between St. Louis and Santa Ana. The service departs St. Louis at 1:20 AM at night, which arrives into Santa Ana at 20:15:00. All services require a transfer, and take on average 44h 55m. The schedules shown below are for the next available departures.

Departing Saturday, November 7, 2026

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    Arrives next day

    Greyhound USAFlixbus USA44h 55m • 1 change

Departing Sunday, November 8, 2026

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    Arrives next day

    Greyhound USAFlixbus USA44h 55m • 1 change

Departing Monday, November 9, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USA44h 55m • 1 change

Departing Tuesday, November 10, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USA44h 55m • 1 change

Frequently asked questions

Want to know about travelling from St. Louis to Santa Ana? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from St. Louis to Santa Ana.ExpandLaunch map view
  • Distance: 1,946.2 mi
  • Duration: 44h 55m

What companies run services between St. Louis, MO, USA and Santa Ana, CA, USA?

You can take a bus from St Louis Bus Station to Santa Ana Bus Stop via Los Angeles Union Station in around 43h 10m.

Operators