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How to get fromSt. Louis to Santa Anaby plane, bus (Greyhound, Amtrak), train (Amtrak), car or train

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There are 9 ways to get from St. Louis to Santa Ana by plane, bus (Greyhound, Amtrak), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to John Wayne Airport Orange County

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to John Wayne Airport Orange County (SNA)plane plane STL - SNA
    7h 30m
    $252–1,138

  2. Fly to Long Beach Airport

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to Long Beach Airport (LGB)plane plane STL - LGB
    10h 21m
    $180–934

  3. Bus

    1. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus bus Greyhound US1210
    2. Take the bus from Los Angeles to Santa Anabus bus Amtrak Thruway Connecting Service
    40h 55m

  4. Train via Kansas City (Amtrak)

    1. Take the train from St. Louis to Kansas Citytrain train Missouri River Runner / ...
    2. Take the train from Kansas City to Fullerton Amtrak Stationtrain train Southwest Chief
    42h 23m
    $181–1,600

  5. Drive 1,805.6 mi

    1. Drive from St. Louis to Santa Anacar car 1,805.6 mi
    28h 47m
    $330–476

  6. Fly to Los Angeles International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Los Angeles International Airport (LAX)plane plane STL - LAX
    2. Take the train from L.A. Union Station to Santa Anatrain train
    9h
    $210–776

  7. Fly to San Diego International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to San Diego International Airport (SAN)plane plane STL - SAN
    2. Take the train from San Diego Old Town Transportation Center to Santa Anatrain train
    8h 59m
    $290–1,332

  8. Fly to Burbank Bob Hope Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Burbank Bob Hope Airport (BUR)plane plane STL - BUR
    2. Take the train from L.A. Union Station to Santa Anatrain train
    9h 23m
    $374–820

  9. Train (Amtrak)

    1. Take the train from St. Louis to Pomona Amtraktrain train Texas Eagle
    2d 13h
    $203–642

Lambert–St. Louis International Airport (STL) to John Wayne Airport Orange County (SNA) flights

Calendar86Weekly Planes
Duration6h 43mAverage Duration
Ticket$220Cheapest Price
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Questions & Answers

What companies run services between St. Louis, MO, USA and Santa Ana, CA, USA?

Southwest Airlines, American Airlines, and three other airlines fly from Lambert–St. Louis International Airport (STL) to John Wayne Airport Orange County (SNA) every 2 hours. Alternatively, you can take a bus from St Louis Bus Station to Santa Ana via Los Angeles Union Station and Los Angeles in around 40h 55m.

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