The average bus between St. Louis and Madison takes 10h 20m and the fastest bus takes 9h 50m. The bus service runs several times per day from St. Louis to Madison. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between St. Louis and Madison. The earliest departure is at 10:00 AM in the morning, and the last departure from St. Louis is at 11:30 PM which arrives into Madison at 9:50 AM. All services require a transfer at Chicago Bus Station and take an average of 10h 20m. The schedules shown below are for the next available departures.

10h 50m • 1 change
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9h 50m • 1 change
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10h 20m • 1 change

10h 50m • 1 change
Arrives next day

9h 50m • 1 change
Arrives next day

10h 20m • 1 change
Want to know about travelling from St. Louis to Madison? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from St. Louis to Madison. However, there are services departing from St. Louis station and arriving at Madison station via Chicago Bus Station station. The journey, including transfers, takes approximately 10h 20m.
St. Louis to Madison bus services, operated by Flixbus USA, depart from St Louis Bus Station.
St. Louis to Madison bus services, operated by Flixbus USA, arrive at 250 N. Lake St - Madison UW Campus station.
Book your St. Louis to Madison bus tickets online with Flixbus USA and Vangalder Bus.
The distance between St. Louis and Madison is 498.9 km. The road distance is 757 km.
You can take a bus from St Louis Bus Station to 250 N. Lake St - Madison UW Campus via Chicago Bus Station and W Jackson Blvd, after S Clinton St in around 10h 50m.