The average bus between St. Louis and Frederick takes 20h 3m and the fastest bus takes 19h 15m. The bus service runs several times per day from St. Louis to Frederick. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between St. Louis and Frederick. The earliest departure is at 2:00 AM at night, and the last departure from St. Louis is at 1:55 PM which arrives into Frederick at 10:20 AM. All services require a transfer, and take on average 20h 3m. The schedules shown below are for the next available departures.
Arrives next day

20h 15m • 1 change
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20h 25m • 1 change
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22h 30m • 1 change
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20h 15m • 1 change
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20h 25m • 1 change
Arrives next day

22h 30m • 1 change
Arrives next day

20h 15m • 1 change
Arrives next day

20h 25m • 1 change
Arrives next day

22h 30m • 1 change
Arrives next day

20h 15m • 1 change
Arrives next day

20h 25m • 1 change
Want to know about travelling from St. Louis to Frederick? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from St. Louis to Frederick. However, there are services departing from St. Louis station and arriving at Frederick station via Pittsburgh Intermodal Station station. The journey, including transfers, takes approximately 20h 3m.
St. Louis to Frederick bus services, operated by Greyhound USA, depart from St Louis Bus Station.
St. Louis to Frederick bus services, operated by Greyhound USA, arrive at Frederick Bus Station.
Book your St. Louis to Frederick bus tickets online with Greyhound USA.
The distance between St. Louis and Frederick is 1,107.2 km. The road distance is 1,289 km.
You can take a bus from St Louis Bus Station to Frederick Bus Station via Pittsburgh Intermodal Station in around 17h 25m.