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St. Louis to Chicago Loop buses

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Trip Overview

The average bus between St. Louis and Chicago Loop takes 6h 21m and the fastest bus takes 6h 15m. The bus service runs several times per day from St. Louis to Chicago Loop. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

6h 21m
Duration
318 mi
Distance
$52
Average price
3 times a day
Frequency

Bus (Flixbus)

best
  1. Take the bus from St Louis Bus Station to Chicago Bus Stationbus bus FlixBus N2521 / ...
6h 19m
$45–72

St. Louis to Chicago Loop bus times

Buses run 3 times a day between St. Louis and Chicago Loop. The earliest departure is at 10:00 AM in the morning, and the last departure from St. Louis is at 11:30 PM which arrives into Chicago Loop at 6:01 AM. All services require a transfer at Chicago Bus Station and take an average of 6h 21m. The schedules shown below are for the next available departures.

Frequently asked questions

Want to know about travelling from St. Louis to Chicago Loop? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from St. Louis to Chicago Loop.ExpandLaunch map view
  • Distance: 318.4 mi
  • Duration: 6h 21m

What companies run services between St. Louis, MO, USA and Chicago Loop, IL, USA?

Flixbus USA operates a bus from St Louis Bus Station to Chicago Bus Station 3 times a day. Tickets cost $40–70 and the journey takes 6h 5m.

Operators

Bus trips from St. Louis

Bus trips to Chicago Loop

Alternative transport options