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St. Louis (Region) to Memphis buses

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Trip Overview

The average bus between St. Louis (Region) and Memphis takes 9h 59m and the fastest bus takes 6h 56m. The bus service runs several times per day from St. Louis (Region) to Memphis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

9h 59m
Duration
306 mi
Distance
$64
Average price
Twice daily
Frequency

St. Louis (Region) to Memphis bus times

Buses run twice daily between St. Louis (Region) and Memphis. The earliest departure is at 1:00 AM at night, and the last departure from St. Louis (Region) is at 4:00 PM which arrives into Memphis at 5:26 AM. All services require a transfer, and take on average 9h 59m. The schedules shown below are for the next available departures.

Departing Sunday, November 8, 2026

  •  → 

    Arrives next day

    Flixbus USAMATA Transit13h 26m • 1 change

Departing Monday, November 9, 2026

  •  → 

    Greyhound USAMATA Transit6h 56m • 1 change
  •  → 

    Arrives next day

    Flixbus USAMATA Transit13h 26m • 1 change

Departing Tuesday, November 10, 2026

  •  → 

    Greyhound USAMATA Transit6h 56m • 1 change
  •  → 

    Arrives next day

    Flixbus USAMATA Transit13h 26m • 1 change

Departing Wednesday, November 11, 2026

  •  → 

    Greyhound USAMATA Transit6h 56m • 1 change
  •  → 

    Arrives next day

    Flixbus USAMATA Transit13h 26m • 1 change

Departing Thursday, November 12, 2026

  •  → 

    Greyhound USAMATA Transit6h 56m • 1 change
  •  → 

    Arrives next day

    Flixbus USAMATA Transit13h 26m • 1 change

Departing Friday, November 13, 2026

  •  → 

    Greyhound USAMATA Transit6h 56m • 1 change

Departing Saturday, November 14, 2026

  •  → 

    Greyhound USAMATA Transit7h 56m • 1 change

Frequently asked questions

Want to know about travelling from St. Louis (Region) to Memphis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from St. Louis (Region) to Memphis.ExpandLaunch map view
  • Distance: 305.9 mi
  • Duration: 9h 59m

What companies run services between St. Louis (Region), MO, USA and Memphis, TN, USA?

Greyhound USA operates a bus from St Louis Bus Station to Memphis Bus Station twice daily. Tickets cost $50–80 and the journey takes 5h 30m. Flixbus USA also services this route once daily.

Operators