The average bus between St. Louis (Region) and Chicago takes 6h 8m and the fastest bus takes 6h 5m. The bus service runs several times per day from St. Louis (Region) to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between St. Louis (Region) and Chicago. The earliest departure is at 10:00 AM in the morning, and the last departure from St. Louis (Region) is at 11:30 PM which arrives into Chicago at 5:45 AM. All services run direct with no transfers required, and take on average 6h 8m. The schedules shown below are for the next available departures.
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Want to know about travelling from St. Louis (Region) to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
Yes, there is a direct bus departing from St. Louis (Region) station and arriving at Chicago station. Services depart 3 times a day, and operate Once daily. The journey takes approximately 6h 8m.
St. Louis (Region) to Chicago bus services, operated by Flixbus USA, depart from St Louis Bus Station.
St. Louis (Region) to Chicago bus services, operated by Flixbus USA, arrive at Chicago Bus Station.
Book your St. Louis (Region) to Chicago bus tickets online with Flixbus USA.
The distance between St. Louis (Region) and Chicago is 421.9 km. The road distance is 511 km.
Flixbus USA operates a bus from St Louis Bus Station to Chicago Bus Station 3 times a day. Tickets cost $40–75 and the journey takes 6h 5m.
