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Siena to Sicily buses

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Trip Overview

The bus between Siena and Sicily takes 16h 23m. The bus runs, on average, 6 times per week from Siena to Sicily. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

16h 23m
Duration
1,212 km
Distance
€130
Average price
6 times a week
Frequency

Siena to Sicily bus times

Buses run 6 times a week between Siena and Sicily. The service departs Siena at 7:00 PM in the evening, which arrives into Sicily at 11:23:00. All services require a transfer at Palermo and take an average of 16h 23m. The schedules shown below are for the next available departures.

Departing Monday, November 9, 2026

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    Arrives next day

    FlixBusAMAT Palermo S.p.A.16h 23m • 1 change

Departing Tuesday, November 10, 2026

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    Arrives next day

    FlixBusAMAT Palermo S.p.A.16h 23m • 1 change

Departing Wednesday, November 11, 2026

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    Arrives next day

    FlixBusAMAT Palermo S.p.A.16h 23m • 1 change

Departing Thursday, November 12, 2026

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    Arrives next day

    FlixBusAMAT Palermo S.p.A.16h 23m • 1 change

Departing Friday, November 13, 2026

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    Arrives next day

    FlixBusAMAT Palermo S.p.A.16h 23m • 1 change

Departing Saturday, November 14, 2026

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    Arrives next day

    FlixBusAMAT Palermo S.p.A.16h 27m • 1 change

Frequently asked questions

Want to know about travelling from Siena to Sicily? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Siena to Sicily.ExpandLaunch map view
  • Distance: 1,211.9 km
  • Duration: 16h 23m

What companies run services between Siena, Italy and Sicily, Italy?

FlixBus operates a bus from Siena to Palermo once daily. Tickets cost €100–160 and the journey takes 16h.

Operators