There are 10 ways to get from Siena to Sicily by bus, plane, train (Trenitalia), train, ferry, car, or car ferry
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus to Florence Peretola Airport, fly to Catania–Fontanarossa Airport
best- Take the bus from Siena-Via Tozzi to Firenze Autostazionebus
- Fly from Florence Peretola Airport (FLR) to Catania–Fontanarossa Airport (CTA)plane FLR - CTA
4h 36mTrain, train to Pisa International Airport, fly to Catania–Fontanarossa Airport
cheapest- Take the train from Siena to Empolitrain
- Take the train from Empoli to Pisa Centraletrain
- Fly from Pisa International Airport (PSA) to Catania–Fontanarossa Airport (CTA)plane PSA - CTA
5h 16m€55–194Bus
- Take the bus from Siena to Palermobus N597
16h 37m€76–127Train (Trenitalia)
- Take the train from Siena to Firenze S.M.N.train Re
- Take the train from Firenze S.M.N. to Roma Terminitrain Fr
- Take the train from Roma Termini to Palermo Centraletrain Ic
16h 59m€109–289Bus, train, ferry
- Take the bus from Siena-Via Tozzi to Grosseto F.S.bus 51G
- Take the train from Grosseto to Civitavecchiatrain Re
- Take the ferry from Port of Civitavecchia to Port of Palermoferry
17h 54mBus to Florence Peretola Airport, fly to Palermo Airport
- Take the bus from Siena-Via Tozzi to Firenze Autostazionebus
- Fly from Florence Peretola Airport (FLR) to Palermo Airport (PMO)plane FLR - PMO
5h 6mTrain, train to Pisa International Airport, fly to Palermo Airport
- Take the train from Siena to Empolitrain
- Take the train from Empoli to Pisa Centraletrain
- Fly from Pisa International Airport (PSA) to Palermo Airport (PMO)plane PSA - PMO
5h 41m€57–226Bus, train to Bologna Guglielmo Marconi Airport, fly to Catania–Fontanarossa Airport
- Take the bus from Siena-Via Tozzi to Firenze Autostazionebus
- Take the train from Firenze S.M.N. to Bologna Centraletrain
- Fly from Bologna Guglielmo Marconi Airport (BLQ) to Catania–Fontanarossa Airport (CTA)plane BLQ - CTA
5h 21mTrain via Chiusi (Trenitalia)
- Take the train from Siena to Chiusi-Chianciano T.train Re
- Take the train from Chiusi-Chianciano T. to Roma Terminitrain Re
- Take the train from Roma Termini to Palermo Centraletrain Ic
17h 54m€103–247Drive, car ferry
- Drive from Siena to Livornocar
- Take the car ferry from Livorno to Port of Palermocarferry
21h 27m€59–87
Siena to Sicily by bus
Questions & Answers
The cheapest way to get from Siena to Sicily is to drive and car ferry which costs €55 - €90 and takes 21h 27m.
The fastest way to get from Siena to Sicily is to train and fly which takes 5h 16m and costs €55 - €200.
No, there is no direct bus from Siena to Sicily. However, there are services departing from Siena and arriving at Piazza Boiardo via Stazione Centrale Pensilina Esterna. The journey, including transfers, takes approximately 16h 37m.
No, there is no direct train from Siena to Sicily. However, there are services departing from Siena and arriving at Palermo Notarbartolo via Firenze S.M.N., Roma Termini and Palermo Centrale. The journey, including transfers, takes approximately 16h 59m.
The distance between Siena and Sicily is 855 km.
The best way to get from Siena to Sicily without a car is to bus which takes 16h 37m and costs €75 - €130.
It takes approximately 4h 36m to get from Siena to Sicily, including transfers.
Siena to Sicily bus services, operated by FlixBus, depart from Siena station.
Siena to Sicily train services, operated by Trenitalia, depart from Siena station.
The best way to get from Siena to Sicily is to bus which takes 16h 37m and costs €75 - €130. Alternatively, you can train, which costs €100 - €290 and takes 16h 59m.
What companies run services between Siena, Italy and Sicily, Italy?
FlixBus operates a bus from Siena to Palermo once daily. Tickets cost €70–130 and the journey takes 16h. Alternatively, you can take a train from Siena to Palermo Notarbartolo via Firenze S.M.N., Roma Termini, and Palermo Centrale in around 16h 59m.
- Website
- ryanair.com
Flights from Pisa International Airport to Palermo Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €35–190
Flights from Pisa International Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- €40–170
Flights from Bologna Guglielmo Marconi Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- €30–180
- Website
- ita-airways.com
Flights from Florence Peretola Airport to Catania–Fontanarossa Airport via Rome
- Ave. Duration
- 3h 48m
- When
- Every day
- Estimated price
- €70–120
Flights from Florence Peretola Airport to Palermo Airport via Rome
- Ave. Duration
- 3h 40m
- When
- Every day
- Estimated price
- €70–150
Flights from Bologna Guglielmo Marconi Airport to Catania–Fontanarossa Airport via Rome
- Ave. Duration
- 3h 35m
- When
- Every day
- Estimated price
- €50–130
- Website
- volotea.com
Flights from Florence Peretola Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 1h 35m
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €26–130
Flights from Florence Peretola Airport to Palermo Airport
- Ave. Duration
- 1h 25m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- €30–130
- Website
- flyulendo.com
Flights from Bologna Guglielmo Marconi Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 1h 45m
- When
- Every day
- Estimated price
- €21–90
- Website
- vueling.com
Flights from Florence Peretola Airport to Catania–Fontanarossa Airport
- Ave. Duration
- 1h 35m
- When
- Wednesday and Saturday
- Estimated price
- €29–150
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Siena to Firenze S.M.N.
- Ave. Duration
- 1h 34m
- Frequency
- Hourly
- Estimated price
- €7–10
- Website
- https://www.trenitalia.com/en.html
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 3h 52m
- Frequency
- 4 times a day
- Estimated price
- €15–23
- Website
- https://www.trenitalia.com/en.html
Train from Grosseto to Civitavecchia
- Ave. Duration
- 1h 11m
- Frequency
- Every 2 hours
- Estimated price
- €7–11
- Website
- https://www.trenitalia.com/en.html
Train from Siena to Empoli
- Ave. Duration
- 1h 2m
- Frequency
- Hourly
- Estimated price
- €5–8
- Website
- https://www.trenitalia.com/en.html
Train from Empoli to Pisa Centrale
- Ave. Duration
- 53 min
- Frequency
- Every 30 minutes
- Estimated price
- €4–7
- Website
- https://www.trenitalia.com/en.html
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 28m
- Frequency
- Twice daily
- Estimated price
- €6–10
- Website
- https://www.trenitalia.com/en.html
Train from Siena to Chiusi-Chianciano T.
- Ave. Duration
- 1h 28m
- Frequency
- Every 2 hours
- Estimated price
- €6–10
- Website
- https://www.trenitalia.com/en.html
Train from Chiusi-Chianciano T. to Roma Termini
- Ave. Duration
- 2h 5m
- Frequency
- Every 4 hours
- Estimated price
- €9–15
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 1h 42m
- Frequency
- Hourly
- Estimated price
- €35–75
- Schedules at
- trenitalia.com
Train from Grosseto to Civitavecchia
- Ave. Duration
- 50 min
- Frequency
- 5 times a day
- Estimated price
- €15–30
- Schedules at
- trenitalia.com
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 37 min
- Frequency
- Every 30 minutes
- Estimated price
- €13–26
- Schedules at
- trenitalia.com
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 2h 40m
- Frequency
- 6 times a week
- Estimated price
- €25–60
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Palermo Centrale
- Ave. Duration
- 11h 44m
- Frequency
- Once daily
- Estimated price
- €85–200
- Website
- https://www.trenitalia.com/en.html
Train from Grosseto to Civitavecchia
- Ave. Duration
- 53 min
- Frequency
- 3 times a day
- Estimated price
- €10–24
- Website
- https://www.trenitalia.com/en.html
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 17m
- Frequency
- Once daily
- Estimated price
- €9–21
- Website
- https://www.trenitalia.com/en.html
Train from Chiusi-Chianciano T. to Roma Termini
- Ave. Duration
- 2h 47m
- Frequency
- 3 times a day
- Estimated price
- €14–35
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- ufficiogruppi@trenitalia.it
- Website
- trenitalia.com
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 12m
- Frequency
- Once daily
- Estimated price
- €27–70
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €45–70
- 2nd Class
- €27–40
- Phone
- +39 055 849 0505
- servizioclienti@at-bus.it
- Website
- at-bus.it
Bus from Siena-Via Tozzi to Firenze Autostazione
- Ave. Duration
- 1h 15m
- Frequency
- Hourly
- Website
- https://www.at-bus.it/en
Bus from Siena-Via Tozzi to Grosseto F.S.
- Ave. Duration
- 1h 15m
- Frequency
- Every 2 hours
- Website
- https://www.at-bus.it/en
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Siena to Palermo
- Ave. Duration
- 16h
- Frequency
- Once daily
- Estimated price
- €70–130
- Website
- https://www.flixbus.co.uk
- Phone
- +39 010 209 4591
- booking@gnv.it
- Website
- gnv.it
Ferry from Port of Civitavecchia to Port of Palermo
- Ave. Duration
- 12h
- Frequency
- Once a week
- Estimated price
- €55–99
- Website
- https://www.gnv.it/en
- Seat
- €55–65
- Cabin
- €93–99
- Phone
- +39.081.496.444
- info@grimaldi.napoli.it
- Website
- grimaldi-lines.com
Car ferry from Livorno to Port of Palermo
- Ave. Duration
- 19h 30m
- Frequency
- 3 times a week
- Estimated price
- €40–60
- Website
- https://www.grimaldi-lines.com/en/
Want to know more about travelling around Italy
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More Questions & Answers
Siena to Sicily bus services, operated by FlixBus, arrive at Palermo station.
Siena to Sicily train services, operated by Trenitalia, arrive at Firenze S.M.N. station.
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