Need a hotel room in Palermo?

Book now
Travel within Italy is: Partially open. See details.

There are 11 ways to get from Siena to Sicily by train, plane, bus, car or ferry

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Train to Florence, fly to Palermo  •  5h 30m

  1. Take the train from Siena to Firenze Rifredi
  2. Fly from Florence (FLR) to Palermo (PMO) FLR - PMO

€50 - €232

Cheapest option

Train, train to Pisa, fly to Palermo  •  5h 53m

  1. Take the train from Siena to Empoli
  2. Take the train from Empoli to Pisa Centrale
  3. Fly from Pisa (PSA) to Palermo (PMO) PSA - PMO

€19 - €91

9 alternative options

Train to Florence, fly to Catania  •  5h 18m

  1. Take the train from Siena to Firenze Rifredi
  2. Fly from Florence (FLR) to Catania (CTA) FLR - CTA

€46 - €181

Train, train to Pisa, fly to Catania  •  5h 41m

  1. Take the train from Siena to Empoli
  2. Take the train from Empoli to Pisa Centrale
  3. Fly from Pisa (PSA) to Catania (CTA) PSA - CTA

€34 - €165

Train, train to Bologna, fly to Palermo  •  6h 44m

  1. Take the train from Siena to Firenze S.M.N.
  2. Take the train from Firenze S.M.N. to Bologna Centrale
  3. Fly from Bologna (BLQ) to Palermo (PMO) BLQ - PMO

€30 - €180

Train, train to Bologna, fly to Catania  •  6h 31m

  1. Take the train from Siena to Firenze S.M.N.
  2. Take the train from Firenze S.M.N. to Bologna Centrale
  3. Fly from Bologna (BLQ) to Catania (CTA) BLQ - CTA

€36 - €174

Bus  •  16h 44m

  1. Take the bus from SIENA - Pza Stazione FS-Fta SENA to PALERMO - PALERMO-P.Cairoli FS Baltour

€46 - €60

Drive, ferry  •  16h 35m

  1. Drive from Siena to Civitavecchia
  2. Take the ferry from Civitavecchia to Palermo

€69 - €144

Train  •  17h 5m

  1. Take the train from Siena to Firenze S.M.N. Re
  2. Take the train from Firenze S.M.N. to Roma Termini Fr / ...
  3. Take the train from Roma Termini to Palermo Centrale Ic

€74 - €166

Train via Chiusi  •  17h 58m

  1. Take the train from Siena to Chiusi-Chianciano T. Re
  2. Take the train from Chiusi-Chianciano T. to Roma Termini Re / ...
  3. Take the train from Roma Termini to Palermo Centrale Ic

€68 - €145

Bus via Florence  •  19h 4m

  1. Take the bus from Siena-Via Tozzi to Firenze Autostazione 131R / ...
  2. Take the bus from Florence to Palermo N597

€66 - €82

Siena to Sicily by train

The train journey time between Siena and Sicily is around 23h 50m and covers a distance of around 1229 km. The fastest train normally takes 23h 41m. Operated by Trenitalia, Trenitalia Frecce, ItaloTreno and others, the Siena to Sicily train service departs from Siena and arrives in Palermo Notarbartolo. Typically six trains run weekly, although weekend and holiday schedules can vary so check in advance.

Train route overview

Average train time:
23h 50m
Fastest train time:
23h 41m
Trains per week:
6
Cheapest price:
€79
Carbon emissions:
64 kg CO2

First and last trains

First train departs at:
20:18
Last train departs at:
20:18

The schedules shown below are for the next available departures.

Siena to Sicily train schedules

Siena → Sicily
Partially open

Travel safe during COVID-19

Rules to follow in Italy

1.5m

Mandatory

Travel within Italy

Observe COVID-19 safety rules
Nationwide control measures in place
Inter-regional travel is permitted

COVID-19 help in Italy

If you need help, visit the national COVID-19 website or call the COVID-19 Helpline 1500

Frequently Asked Questions


There are currently travel restrictions within Italy.

Explore options for future travel

Domestic travel is not restricted, but some conditions may apply

  • Face masks are mandatory
  • There is a social distancing requirement of 1.5 metres
  • Observe COVID-19 safety rules
  • Nationwide control measures in place
  • Inter-regional travel is permitted

Explore travel options

The national COVID-19 helpline number in Sicily is 1500.

Wearing a face mask on public transport in Sicily is mandatory.

The social distance requirement in Sicily is 1.5 metres.

Make yourself known to an official member of staff and/or call the national coronavirus helpline number on 1500.

Last updated: 20 Jun 2021
Exceptions may apply, for full details: European Union.

We're working around the clock to bring you the latest COVID-19 travel updates.
This information is compiled from official sources. To the best of our knowledge, it is correct as of the last update.
Visit Rome2rio travel advice for general help.

Questions & Answers

The cheapest way to get from Siena to Sicily is to train and fly which costs €18 - €95 and takes 5h 53m.

More details

The quickest way to get from Siena to Sicily is to train and fly which costs €45 - €190 and takes 5h 18m.

More details

No, there is no direct bus from Siena to Sicily. However, there are services departing from SIENA - Pza Stazione FS-Fta SENA and arriving at Piazza Boiardo via Stazione Centrale - Pensilina Esterna. The journey, including transfers, takes approximately 16h 44m.

More details

No, there is no direct train from Siena to Sicily. However, there are services departing from Siena and arriving at Palermo Notarbartolo via Firenze S.M.N., Roma Termini and Palermo Centrale. The journey, including transfers, takes approximately 17h 5m.

More details

The distance between Siena and Sicily is 680 km.

The best way to get from Siena to Sicily without a car is to bus which takes 16h 44m and costs €45 - €60.

More details

It takes approximately 5h 30m to get from Siena to Sicily, including transfers.

More details

Siena to Sicily bus services, operated by Baltour, depart from SIENA - Pza Stazione FS-Fta SENA station.

More details

Siena to Sicily train services, operated by Trenitalia, depart from Siena station.

More details

The best way to get from Siena to Sicily is to bus which takes 16h 44m and costs €45 - €60. Alternatively, you can train, which costs €70 - €170 and takes 17h 5m.

Mode details

Map of how to get from Siena to Sicily.
Launch map view
  • Distance: 680.4 km
  • Duration: 5h 30m

What companies run services between Siena, Italy and Sicily, Italy?

Baltour operates a bus from SIENA - Pza Stazione FS-Fta SENA to PALERMO - PALERMO-P.Cairoli FS twice daily. Tickets cost €40 - €60 and the journey takes 16h 10m. Alternatively, you can take a train from Siena to Palermo via Firenze S.M.N., Roma Termini, and Palermo Centrale in around 17h 5m.

Airlines
Alitalia
Website
alitalia.com
Flights from Florence to Palermo via Rome
Ave. Duration
3h 16m
When
Every day
Estimated price
€65 - €410
Flights from Florence to Catania via Rome
Ave. Duration
3h 26m
When
Every day
Estimated price
€65 - €140
Flights from Pisa to Palermo via Rome
Ave. Duration
3h 6m
When
Every day
Estimated price
€70 - €260
Flights from Pisa to Catania via Rome
Ave. Duration
3h 28m
When
Every day
Estimated price
€80 - €290
Flights from Bologna to Palermo via Rome
Ave. Duration
3h 3m
When
Every day
Estimated price
€50 - €230
Flights from Bologna to Catania via Rome
Ave. Duration
3h 37m
When
Every day
Estimated price
€45 - €170
Ryanair
Website
ryanair.com
Flights from Pisa to Palermo
Ave. Duration
1h 20m
When
Every day
Estimated price
€17 - €100
Flights from Pisa to Catania
Ave. Duration
1h 30m
When
Every day
Estimated price
€30 - €140
Flights from Bologna to Palermo
Ave. Duration
1h 25m
When
Every day
Estimated price
€20 - €110
Flights from Bologna to Palermo via Bari
Ave. Duration
3h 20m
When
Friday and Sunday
Estimated price
€20 - €110
Flights from Bologna to Catania
Ave. Duration
1h 35m
When
Every day
Estimated price
€25 - €130
Vueling Airlines
Website
vueling.com
Flights from Florence to Palermo
Ave. Duration
1h 25m
When
Monday, Thursday, Friday and Sunday
Estimated price
€50 - €550
Flights from Florence to Catania
Ave. Duration
1h 35m
When
Monday, Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
€35 - €220
Wizz Air
Website
wizzair.com
Flights from Pisa to Palermo
Ave. Duration
1h 20m
When
Every day
Estimated price
€9 - €90
Flights from Pisa to Catania
Ave. Duration
1h 30m
When
Monday, Wednesday, Thursday, Friday and Sunday
Estimated price
€20 - €120
Flights from Bologna to Palermo
Ave. Duration
1h 25m
When
Every day
Estimated price
€16 - €90
Flights from Bologna to Catania
Ave. Duration
1h 40m
When
Every day
Estimated price
€30 - €110
Air Dolomiti
Website
airdolomiti.it
Flights from Florence to Palermo
Ave. Duration
1h 25m
When
Wednesday, Friday and Sunday
Estimated price
€80 - €280
Flights from Florence to Catania
Ave. Duration
1h 35m
When
Monday, Thursday, Friday and Sunday
Estimated price
€60 - €160
Tayaran Jet
Website
en.tayaranjet.com
Flights from Bologna to Palermo
Ave. Duration
1h 55m
When
Every day
Estimated price
€35 - €380
Flights from Bologna to Catania
Ave. Duration
1h 35m
When
Every day
Estimated price
€40 - €360
Train operators
Trenitalia

The primary train operator in Italy, Trenitalia was created in the year 2000. Trenitalia offers national rail connections in Italy as well as international connections to Austria, France, Germany and Switzerland. The company operates regional and long-distance trains, as well as high-speed trains called Frecce that travel on specialised tracks on speeds of up to 360km/h. Trenitalia tickets are available online, in stations across the country or from many travel agents that offer bookings.

Contact Details
Phone
+39 06 68475475
Website
trenitalia.com
Train from Siena to Firenze Rifredi
Ave. Duration
1h 25m
Frequency
Hourly
Estimated price
€6 - €14
Website
Trenitalia
1st Class
€12 - €14
Train from Siena to Empoli
Ave. Duration
1h 2m
Frequency
Hourly
Estimated price
€4 - €10
Website
Trenitalia
1st Class
€8 - €10
Train from Empoli to Pisa Centrale
Ave. Duration
30 min
Frequency
Every 30 minutes
Estimated price
€3 - €8
Website
Trenitalia
1st Class
€7 - €8
Train from Siena to Firenze S.M.N.
Ave. Duration
1h 32m
Frequency
Hourly
Estimated price
€6 - €14
Website
Trenitalia
1st Class
€12 - €14
Train from Firenze S.M.N. to Bologna Centrale
Ave. Duration
1h 45m
Frequency
6 times a week
Estimated price
€6 - €14
Website
Trenitalia
1st Class
€12 - €14
Train from Firenze S.M.N. to Roma Termini
Ave. Duration
3h 41m
Frequency
6 times a week
Estimated price
€17 - €35
Website
Trenitalia
1st Class
€32 - €35
Train from Siena to Chiusi-Chianciano T.
Ave. Duration
1h 26m
Frequency
Every 2 hours
Estimated price
€6 - €13
Website
Trenitalia
1st Class
€12 - €13
Train from Chiusi-Chianciano T. to Roma Termini
Ave. Duration
2h
Frequency
Every 3 hours
Estimated price
€10 - €21
Website
Trenitalia
1st Class
€19 - €21
Trenitalia Frecce

Trenitalia’s high-speed Frecce trains run on specialised tracks and have a greater level of service and comfort than InterCity and regional trains. There are three types of Frecce trains: Frecciarossa, (the fastest; connects major Italian cities); Frecciargento (mostly connect Rome to other Italian cities); and Frecciabianca (the slowest Frecce trains). Frecciarossa trains offer four classes of service, all with free Wi-Fi: Standard, Premium, Business and Executive. All Frecce tickets include a seat reservation and must be purchased before boarding the train.

Contact Details
Phone
+39 06 68475475
Website
trenitalia.com
Train from Firenze S.M.N. to Bologna Centrale
Ave. Duration
38 min
Frequency
Hourly
Estimated price
€11 - €45
Website
Trenitalia Frecce
Super Economy
€11 - €15
Base Standard
€25 - €35
Base Premium
€30 - €45
Train from Firenze S.M.N. to Roma Termini
Ave. Duration
1h 36m
Frequency
Hourly
Estimated price
€21 - €75
Website
Trenitalia Frecce
Super Economy
€21 - €29
Base Standard
€40 - €55
Base Premium
€50 - €75
Train from Chiusi-Chianciano T. to Roma Termini
Ave. Duration
1h 2m
Frequency
6 times a week
Estimated price
€14 - €55
Website
Trenitalia Frecce
Super Economy
€14 - €20
Base Standard
€30 - €45
Base Premium
€35 - €55
ItaloTreno

Private train company Italotreno operates high-speed trains in Italy on the same tracks as Trenitalia. The routes service 21 stations across the country, including popular routes Milan-Florence, Rome-Venice and Bologna-Naples. Choose from four classes of service, all with free Wi-Fi: Smart, Comfort, Prima and Club Executive. Italo also operates Italobus – an integrated train-bus service that takes passengers from the main train stations to other Italian cities.

Contact Details
Phone
+39 060708
Website
italotreno.it
Train from Firenze Santa Maria Novella to Bologna Centrale Station
Ave. Duration
38 min
Frequency
Every 3 hours
Estimated price
€12 - €40
Website
Italo Treno
Smart Economy
€14 - €21
Smart Low Cost
€12 - €17
Smart Flex
€26 - €40
Train from Firenze Santa Maria Novella to Roma Termini
Ave. Duration
1h 37m
Frequency
4 times a day
Estimated price
€19 - €55
Website
Italo Treno
Smart Economy
€21 - €30
Smart Low Cost
€19 - €27
Smart Flex
€40 - €55
Trenitalia Intercity

Trenitalia’s Intercity (IC) trains are slower than the high-speed Frecce trains but are still a good way to travel between major cities and towns, with routes including Rome to Naples, Venice to Bologna and Milan to Genoa. Tickets usually open for booking 90 days ahead of travel, and you’ll need make a seat reservation before boarding. All IC trains have 1st and 2nd class carriages as well as a bar buffet car, air conditioning and power sockets. InterCity trains that run at night are called InterCity Notte (ICN).

Contact Details
Phone
+39 06 68475475
Website
trenitalia.com
Train from Firenze S.M.N. to Roma Termini
Ave. Duration
2h 40m
Frequency
6 times a week
Estimated price
€16 - €24
Website
Trenitalia Intercity
2nd Class
€16 - €24
Train from Roma Termini to Palermo Centrale
Ave. Duration
11h 59m
Frequency
Once daily
Estimated price
€50 - €75
Website
Trenitalia Intercity
2nd Class
€50 - €75
Train from Chiusi-Chianciano T. to Roma Termini
Ave. Duration
1h 21m
Frequency
Twice daily
Estimated price
€10 - €15
Website
Trenitalia Intercity
2nd Class
€10 - €15
Bus operators
Baltour
Phone
+39 0861 1991900
Email
info@baltour.it
Website
global.flixbus.com
Bus from SIENA - Pza Stazione FS-Fta SENA to PALERMO - PALERMO-P.Cairoli FS
Ave. Duration
16h 10m
Frequency
Twice daily
Estimated price
€40 - €60
Website
Baltour
FlixBus

One of Europe’s leading bus companies, Flixbus serves 2000+ destinations in 29 countries, including Germany, France, Italy, Austria, the Netherlands and Croatia and into Scandinavia and eastern Europe, as well as some US cities. Coaches have toilets, free WiFi and power outlets, plus snacks and drinks for purchase on board. Flixbus is a good choice for the budget-conscious traveller; purchase tickets in advance for the cheapest fares (note: there is no option to reserve a seat in advance).

Rome2rio's guide to FlixBus
Contact Details
Phone
+49 1807 123 99 123
Email
info@flixbus.de
Website
flixbus.de
Bus from Florence to Palermo
Ave. Duration
15h 50m
Frequency
Once daily
Estimated price
€55 - €70
Website
flixbus.co.uk
Ferry operators

Want to know more about travelling around Italy

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

The quickest flight from Florence Airport to Palermo Airport is the direct flight which takes 1h 25m.

Search flights

Siena to Sicily bus services, operated by Baltour, arrive at PALERMO - PALERMO-P.Cairoli FS station.

More details

Siena to Sicily train services, operated by Trenitalia Intercity, arrive at Palermo Centrale station.

More details

Air Dolomiti, Vueling Airlines and Alitalia offer flights from Florence Airport to Palermo Airport.

Search flights

Book your Siena to Sicily train tickets online with Omio.

Search and book

There are 43+ hotels available in Sicily. Prices start at €75 per night.

More details