The average bus between Siena and Rome Termini takes 3h 16m and the fastest bus takes 2h 57m. The bus service runs several times per day from Siena to Rome Termini. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 3 hours between Siena and Rome Termini. The earliest departure is at 5:35 AM in the morning, and the last departure from Siena is at 10:25 PM which arrives into Rome Termini at 1:35 AM. All services require a transfer at Roma, Autostazione Tiburtina and take an average of 3h 16m. The schedules shown below are for the next available departures.

3h 30m • 1 change

3h 24m • 1 change

3h 5m • 1 change

3h 11m • 1 change

3h 26m • 1 change

3h 22m • 1 change

3h 5m • 1 change

3h 14m • 1 change

3h 26m • 1 change

3h 22m • 1 change

3h 5m • 1 change

3h 14m • 1 change

3h 26m • 1 change

3h 22m • 1 change

3h 5m • 1 change

3h 14m • 1 change

3h 26m • 1 change

3h 22m • 1 change

3h 5m • 1 change

3h 14m • 1 change

3h 26m • 1 change

3h 22m • 1 change

3h 5m • 1 change

3h 14m • 1 change
Want to know about travelling from Siena to Rome Termini? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Siena to Rome Termini. However, there are services departing from Siena station and arriving at Rome Termini station via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 3h 16m.
Siena to Rome Termini bus services, operated by FlixBus, depart from Siena station.
Siena to Rome Termini bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
Book your Siena to Rome Termini bus tickets online with FlixBus, ATAC S.p.A. Azienda per la mobilità and AutoLinee Moretti.
The distance between Siena and Rome Termini is 184.2 km. The road distance is 233 km.
FlixBus operates a bus from Siena to Roma, Autostazione Tiburtina every 3 hours. Tickets cost €18–35 and the journey takes 2h 50m. AutoLinee Moretti also services this route 3 times a week.