The average bus between Siena and Milazzo takes 18h 47m and the fastest bus takes 12h 50m. The bus service runs several times per day from Siena to Milazzo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Siena and Milazzo. The earliest departure is at 5:35 AM in the morning, and the last departure from Siena is at 7:00 PM which arrives into Milazzo at 7:50 AM. All services require a transfer, and take on average 18h 47m. The schedules shown below are for the next available departures.
Arrives next day

25h 15m • 1 change
Arrives next day

12h 50m • 1 change
Arrives next day

25h 15m • 1 change
Arrives next day

12h 50m • 1 change
Want to know about travelling from Siena to Milazzo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Siena to Milazzo. However, there are services departing from Siena station and arriving at Milazzo station via Messina. The journey, including transfers, takes approximately 18h 47m.
Siena to Milazzo bus services, operated by FlixBus, depart from Siena station.
Siena to Milazzo bus services, operated by FlixBus, arrive at Milazzo station.
The distance between Siena and Milazzo is 655.4 km. The road distance is 945 km.
You can take a bus from Siena to Milazzo via Messina in around 13h 30m.