The average bus between Siegen and Mainz takes 5h 18m and the fastest bus takes 3h 35m. The bus service runs several times per day from Siegen to Mainz. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Siegen and Mainz. The earliest departure is at 6:50 AM in the morning, and the last departure from Siegen is at 6:20 PM which arrives into Mainz at 12:55 AM. All services require a transfer, and take on average 5h 18m. The schedules shown below are for the next available departures.

3h 35m • 1 change

5h 45m • 1 change
Arrives next day

6h 35m • 1 change

3h 35m • 1 change

5h 45m • 1 change
Arrives next day

6h 35m • 1 change

3h 35m • 1 change

5h 45m • 1 change
Arrives next day

6h 35m • 1 change

3h 35m • 1 change

5h 45m • 1 change
Arrives next day

6h 35m • 1 change

3h 35m • 1 change

5h 45m • 1 change
Arrives next day

6h 35m • 1 change
Want to know about travelling from Siegen to Mainz? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Siegen to Mainz. However, there are services departing from Siegen station and arriving at Mainz station via Frankfurt central train station station. The journey, including transfers, takes approximately 5h 18m.
Siegen to Mainz bus services, operated by FlixBus, depart from Siegen station.
Siegen to Mainz bus services, operated by FlixBus, arrive at Mainz central train station.
Book your Siegen to Mainz bus tickets online with FlixBus.
The distance between Siegen and Mainz is 100.7 km. The road distance is 172 km.
You can take a bus from Siegen to Mainz central train station via Frankfurt central train station in around 3h 50m.