The average bus between Santander and Milan takes 24h 28m and the fastest bus takes 21h 5m. The bus service runs several times per day from Santander to Milan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Santander and Milan. The earliest departure is at 6:45 AM in the morning, and the last departure from Santander is at 8:00 PM which arrives into Milan at 6:00 AM. All services require a transfer at San Sebastián - Bus Station and take an average of 24h 28m. The schedules shown below are for the next available departures.
Arrives next day


21h 5m • 2 changes
Arrives +2 days


34h • 2 changes
Arrives next day


23h 15m • 2 changes
Arrives next day


21h 5m • 2 changes
Arrives next day


23h 15m • 2 changes
Arrives next day


21h 5m • 2 changes
Arrives +2 days


34h • 2 changes
Want to know about travelling from Santander to Milan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Santander to Milan. However, there are services departing from Santander station and arriving at Milan station via Estación de Autobuses Donostia-San Sebastián. The journey, including transfers, takes approximately 24h 28m.
Santander to Milan bus services, operated by ALSA, depart from Santander E.A. station.
Santander to Milan bus services, operated by ALSA, arrive at Milano, Autostazione Lampugnano station.
Book your Santander to Milan bus tickets online with ALSA and BlaBlaCar Bus.
The distance between Santander and Milan is 1,053.6 km. The road distance is 1,414 km.
You can take a bus from Santander E.A. to Milano, Autostazione Lampugnano via San Sebastián - Bus Station and Bordeaux - Belcier Bus Stop in around 21h 9m.