The average bus between Milan and Rome takes 7h 54m and the fastest bus takes 6h 45m. The bus service runs several times per day from Milan to Rome. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Milan and Rome. The earliest departure is at 1:10 AM at night, and the last departure from Milan is at 9:20 PM which arrives into Rome at 6:10 AM. All services require a transfer, and take on average 7h 54m. The schedules shown below are for the next available departures.

7h 40m • 1 change

7h 35m • 1 change
Arrives next day

12h 45m • 1 change

7h 30m • 1 change

6h 45m • 1 change

7h 40m • 1 change

7h 45m • 1 change

7h 30m • 1 change

6h 45m • 1 change

7h 40m • 1 change

7h 45m • 1 change

7h 30m • 1 change

6h 45m • 1 change

7h 40m • 1 change

7h 45m • 1 change

7h 30m • 1 change

6h 45m • 1 change

7h 40m • 1 change

7h 45m • 1 change

7h 30m • 1 change

6h 45m • 1 change

7h 40m • 1 change

8h 5m • 1 change
Want to know about travelling from Milan to Rome? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Milan to Rome. However, there are services departing from Milan station and arriving at Rome station via Florence Villa Constanza Bus Station station. The journey, including transfers, takes approximately 7h 54m.
Milan to Rome bus services, operated by FlixBus, depart from Milano, San Donato M3 station.
Milan to Rome bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
Book your Milan to Rome bus tickets online with FlixBus.
The distance between Milan and Rome is 477.3 km. The road distance is 565 km.
You can take a bus from Milano, San Donato M3 to Roma, Autostazione Tiburtina via Florence Villa Constanza Bus Station in around 7h 7m.