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Santa Rosa to Des Moines buses

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Trip Overview

The bus between Santa Rosa and Des Moines takes 47h 30m. The bus runs, on average, 3 times per week from Santa Rosa to Des Moines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

47h 30m
Duration
2,024 mi
Distance
$422
Average price
3 times a week
Frequency

Santa Rosa to Des Moines bus times

Buses run 3 times a week between Santa Rosa and Des Moines. The service departs Santa Rosa at 7:25 AM in the morning, which arrives into Des Moines at 08:55:00. All services require a transfer at 1st St & Mission St and take an average of 47h 30m. The schedules shown below are for the next available departures.

Departing Monday, November 16, 2026

  •  → 

    Arrives +2 days

    Golden Gate TransitGreyhound USAGreyhound USAGreyhound USA47h 30m • 3 changes

Departing Tuesday, November 17, 2026

  •  → 

    Arrives +2 days

    Golden Gate TransitGreyhound USAGreyhound USAGreyhound USA47h 30m • 3 changes

Departing Wednesday, November 18, 2026

  •  → 

    Arrives +2 days

    Golden Gate TransitGreyhound USAGreyhound USAGreyhound USA47h 30m • 3 changes

Frequently asked questions

Want to know about travelling from Santa Rosa to Des Moines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Santa Rosa to Des Moines.ExpandLaunch map view
  • Distance: 2,023.8 mi
  • Duration: 47h 30m

What companies run services between Santa Rosa, CA, USA and Des Moines, IA, USA?

You can take a bus from Santa Rosa Transit Mall-Bay S1 to Des Moines via 1st St & Mission St, San Francisco Bus Station, Sparks Transit Center, and Denver Union Station in around 45h.

Operators