The average bus between Rome and Spadafora takes 14h 5m and the fastest bus takes 10h 15m. The bus service runs several times per day from Rome to Spadafora. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Rome and Spadafora. The earliest departure is at 1:20 AM at night, and the last departure from Rome is at 9:00 PM which arrives into Spadafora at 10:45 AM. All services require a transfer, and take on average 14h 5m. The schedules shown below are for the next available departures.

10h 30m • 1 change
Arrives next day

21h 20m • 1 change
Arrives next day

10h 15m • 1 change

10h 30m • 1 change
Arrives next day

21h 20m • 1 change
Arrives next day

10h 15m • 1 change

10h 30m • 1 change
Arrives next day

21h 20m • 1 change
Arrives next day

10h 15m • 1 change
Want to know about travelling from Rome to Spadafora? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Rome to Spadafora. However, there are services departing from Rome station and arriving at Spadafora station via Messina. The journey, including transfers, takes approximately 14h 5m.
Rome to Spadafora bus services, operated by FlixBus, depart from Roma, Autostazione Tiburtina station.
Rome to Spadafora bus services, operated by FlixBus, arrive at Messina station.
The distance between Rome and Spadafora is 476.6 km. The road distance is 703 km.
FlixBus operates a bus from Roma, Autostazione Tiburtina to Messina 3 times a day. Tickets cost €45–85 and the journey takes 9h 30m. Autoservizi Salemi also services this route once daily.