The average bus between Rome Termini and Milan takes 8h 32m and the fastest bus takes 8h. The bus service runs several times per day from Rome Termini to Milan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Rome Termini and Milan. The earliest departure is at 5:54 AM in the morning, and the last departure from Rome Termini is at 11:24 PM which arrives into Milan at 8:30 AM. All services require a transfer at Termini and take an average of 8h 32m. The schedules shown below are for the next available departures.

8h 40m • 1 change
8h 23m • 1 change
8h 1m • 1 changeArrives next day

8h • 1 change
8h 38m • 1 change
8h 23m • 1 change
8h 17m • 1 changeArrives next day

8h 7m • 1 change
8h 38m • 1 change
8h 23m • 1 change
8h 17m • 1 changeArrives next day

8h 7m • 1 changeWant to know about travelling from Rome Termini to Milan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Rome Termini to Milan. However, there are services departing from Rome Tiburtina Largo Mazzoni station and arriving at Milano, San Donato M3 station via Milano, San Donato M3 station. The journey, including transfers, takes approximately 8h 32m.
Rome Termini to Milan bus services, operated by Itabus S.p.A., depart from Rome Tiburtina Largo Mazzoni station.
Rome Termini to Milan bus services, operated by Itabus S.p.A., arrive at Milano, San Donato M3 station.
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The distance between Rome Termini and Milan is 477.1 km. The road distance is 571 km.
Itabus S.p.A. operates a bus from Rome Tiburtina Largo Mazzoni to Milano, San Donato M3 once daily. Tickets cost €30–55 and the journey takes 7h 30m.