Rome2Rio

Rochester to Indianapolis buses

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Trip Overview

The bus between Rochester and Indianapolis takes 22h 10m. There is at least one bus per day from Rochester to Indianapolis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

22h 10m
Duration
596 mi
Distance
$125
Average price
Once daily
Frequency

Rochester to Indianapolis bus times

Buses run once daily between Rochester and Indianapolis. The service departs Rochester at 9:15 PM at night, which arrives into Indianapolis at 19:25:00. All services require a transfer at Cleveland Bus Station and take an average of 22h 10m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

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    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA22h 10m • 2 changes

Departing Wednesday, November 11, 2026

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    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA22h 10m • 2 changes

Departing Thursday, November 12, 2026

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    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA22h 10m • 2 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA22h 10m • 2 changes

Departing Saturday, November 14, 2026

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    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA22h 10m • 2 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA22h 10m • 2 changes

Departing Monday, November 16, 2026

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    Arrives next day

    Greyhound USAGreyhound USAGreyhound USA22h 10m • 2 changes

Frequently asked questions

Want to know about travelling from Rochester to Indianapolis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Rochester to Indianapolis.ExpandLaunch map view
  • Distance: 596 mi
  • Duration: 22h 10m

What companies run services between Rochester, NY, USA and Indianapolis, IN, USA?

You can take a bus from Rochester Bus Stop to Indianapolis Union Station via Cleveland Bus Station and Toledo Bus Stop in around 13h 10m.

Operators