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How to get fromRochester to Indianapolisby plane, train, bus, bus (Greyhound), car, bus (Flixbus, Greyhound), or train (Amtrak)

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There are 7 ways to get from Rochester to Indianapolis by plane, train, bus, bus (Greyhound), car, bus (Flixbus, Greyhound), or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Rochester

    best
    1. Fly from Rochester (ROC) to Indianapolis (IND)plane plane ROC - IND
    5h 1m
    $139–772

  2. Bus

    cheapest
    1. Take the bus from Rochester Bus Stop to Buffalobus bus
    2. Take the bus from Buffalo to Columbusbus bus
    3. Take the bus from Columbus to Indianapolisbus bus
    13h 25m
    $88–144

  3. Train, bus

    1. Take the train from Rochester to Toledotrain train Lake Shore Limited
    2. Take the bus from Toledo to Indianapolisbus bus Bsb 15
    11h 49m
    $217–366

  4. Bus via Toledo (Greyhound)

    1. Take the bus from Rochester Bus Stop to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Toledo Bus Stopbus bus
    3. Take the bus from Toledo Bus Stop to Indianapolis Union Stationbus bus
    13h 10m
    $101–158

  5. Drive  563.5 mi

    1. Drive from Rochester to Indianapoliscar car 563.5 mi
    9h 46m
    $103–149

  6. Bus to Buffalo Niagara International Airport, fly

    1. Take the bus from Rochester Bus Stop to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Indianapolis (IND)plane plane BUF - IND
    6h 46m
    $102–567

  7. Train (Amtrak)

    1. Take the train from Rochester to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    17h 37m
    $425–668

Rochester to Indianapolis by train and bus

Calendar7Weekly Services
Duration11h 49mAverage Duration
Ticket$217Cheapest Price
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Comparing Your Travel Options

Map of how to get from Rochester to Indianapolis.ExpandLaunch map view
  • Distance: 524.2 mi
  • Duration: 5h 1m

What companies run services between Rochester, NY, USA and Indianapolis, IN, USA?

Delta, Southwest Airlines, and two other airlines fly from Rochester (ROC) to Indianapolis (IND) hourly. Alternatively, you can take a bus from Rochester Bus Stop to Indianapolis Union Station via Cleveland Bus Station and Toledo Bus Stop in around 13h 10m.

Airlines
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Bus operators

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Need to know: Greyhound

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