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Presque Isle to Milwaukee buses

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Trip Overview

The average bus between Presque Isle and Milwaukee takes 37h 10m and the fastest bus takes 34h 35m. The bus runs, on average, 6 times per week from Presque Isle to Milwaukee. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

37h 10m
Duration
1,714 mi
Distance
$333
Average price
6 times a week
Frequency

Presque Isle to Milwaukee bus times

Buses run 6 times a week between Presque Isle and Milwaukee. The service departs Presque Isle at 7:25 AM in the morning, which arrives into Milwaukee at 08:35:00. All services require a transfer at Bangor, ME and take an average of 37h 10m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

  •  → 

    Arrives +2 days

    Cyr Bus LineAmtrak ThruwayFlixbus USAFlixbus USAGreyhound USA2d 2h • 4 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives next day

    Cyr Bus LineAmtrak ThruwayFlixbus USAFlixbus USAGreyhound USA34h 35m • 4 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives next day

    Cyr Bus LineAmtrak ThruwayFlixbus USAFlixbus USAGreyhound USA34h 35m • 4 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    Cyr Bus LineAmtrak ThruwayFlixbus USAFlixbus USAGreyhound USA34h 35m • 4 changes

Departing Sunday, November 15, 2026

  •  → 

    Arrives next day

    Cyr Bus LineAmtrak ThruwayFlixbus USAFlixbus USAGreyhound USA34h 35m • 4 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    Cyr Bus LineAmtrak ThruwayFlixbus USAFlixbus USAGreyhound USA34h 35m • 4 changes

Frequently asked questions

Want to know about travelling from Presque Isle to Milwaukee? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Presque Isle to Milwaukee.ExpandLaunch map view
  • Distance: 1,714.2 mi
  • Duration: 37h 10m

What companies run services between Presque Isle, ME, USA and Milwaukee, WI, USA?

You can take a bus from Presque Isle, Maine to Milwaukee Intermodal Station via Bangor, ME, Bangor Transportation Center, Boston, MA - South Station, Boston, New York Midtown, and Chicago Bus Station in around 38h 2m.

Operators