The average bus between Prague and Perugia takes 21h 12m and the fastest bus takes 20h 15m. There is at least one bus per day from Prague to Perugia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Prague and Perugia. The earliest departure is at 5:30 PM in the evening, and the last departure from Prague is at 9:25 PM which arrives into Perugia at 7:15 PM. All services require a transfer, and take on average 21h 12m. The schedules shown below are for the next available departures.
Arrives next day

20h 15m • 1 change
Arrives next day

20h 40m • 1 change
Arrives next day

20h 15m • 1 change
Arrives next day

20h 40m • 1 change
Want to know about travelling from Prague to Perugia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Prague to Perugia. However, there are services departing from Prague station and arriving at Perugia station via Florence Villa Constanza Bus Station station. The journey, including transfers, takes approximately 21h 12m.
Prague to Perugia bus services, operated by FlixBus, depart from Praha, ÚAN Florenc station.
Prague to Perugia bus services, operated by FlixBus, arrive at Perugia station.
Book your Prague to Perugia bus tickets online with FlixBus.
The distance between Prague and Perugia is 791 km. The road distance is 1,193 km.
You can take a bus from Praha, ÚAN Florenc to Perugia via Florence Villa Constanza Bus Station in around 18h 45m.