The average bus between Portland, ME and Chicago takes 30h 18m and the fastest bus takes 24h 55m. The bus service runs several times per day from Portland, ME to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Portland, ME and Chicago. The earliest departure is at 12:30 PM in the afternoon, and the last departure from Portland, ME is at 8:00 PM which arrives into Chicago at 6:10 AM. All services require a transfer at Boston, MA - South Station and take an average of 30h 18m. The schedules shown below are for the next available departures.
Arrives next day


23h 55m • 2 changes
Arrives +2 days


34h 10m • 2 changes
Arrives next day


23h 55m • 2 changes
Arrives +2 days


34h 10m • 2 changes
Arrives next day


30h 25m • 2 changes
Arrives +2 days


34h 10m • 2 changes
Want to know about travelling from Portland, ME to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Portland, ME to Chicago. However, there are services departing from Portland, ME station and arriving at Chicago station via Boston, MA - South Station station. The journey, including transfers, takes approximately 30h 18m.
Portland, ME to Chicago bus services, operated by Amtrak Thruway, depart from Portland, ME station.
Portland, ME to Chicago bus services, operated by Amtrak Thruway, arrive at Chicago Bus Station.
The distance between Portland, ME and Chicago is 1,426.3 km. The road distance is 1,949 km.
You can take a bus from Portland, ME to Chicago Bus Station via Boston, MA - South Station, Boston, and New York Midtown in around 25h 3m.