Rome2Rio

Portland, ME to Buffalo buses

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Trip Overview

The bus between Portland, ME and Buffalo takes 12h 5m. There is at least one bus per day from Portland, ME to Buffalo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

12h 5m
Duration
580 mi
Distance
$127
Average price
Once daily
Frequency

Portland, ME to Buffalo bus times

Buses run once daily between Portland, ME and Buffalo. The service departs Portland, ME at 10:30 AM in the morning, which arrives into Buffalo at 22:35:00. All services require a transfer at Boston, MA - South Station and take an average of 12h 5m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

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    Amtrak ThruwayGreyhound USA12h 5m • 1 change

Departing Wednesday, November 11, 2026

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    Amtrak ThruwayGreyhound USA12h 5m • 1 change

Departing Thursday, November 12, 2026

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    Amtrak ThruwayGreyhound USA12h 5m • 1 change

Departing Friday, November 13, 2026

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    Amtrak ThruwayGreyhound USA12h 5m • 1 change

Departing Saturday, November 14, 2026

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    Amtrak ThruwayGreyhound USA12h 5m • 1 change

Departing Sunday, November 15, 2026

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    Amtrak ThruwayGreyhound USA12h 5m • 1 change

Departing Monday, November 16, 2026

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    Amtrak ThruwayGreyhound USA12h 5m • 1 change

Frequently asked questions

Want to know about travelling from Portland, ME to Buffalo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Portland, ME to Buffalo.ExpandLaunch map view
  • Distance: 580.5 mi
  • Duration: 12h 5m

What companies run services between Portland, ME, USA and Buffalo, NY, USA?

You can take a bus from Portland, ME to Buffalo via Boston, MA - South Station and Boston in around 13h.

Operators