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How to get fromPortland, ME to Buffaloby plane, bus (Amtrak, Greyhound, Flixbus), bus, train, car or train (Amtrak)

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There are 9 ways to get from Portland, ME to Buffalo by plane, bus (Amtrak, Greyhound, Flixbus), bus, train, car, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Portland to Buffalo Niagara International Airport

    best
    1. Fly from Portland (PWM) to Buffalo Niagara International Airport (BUF)plane plane PWM - BUF
    5h 59m
    $248–1,443

  2. Bus

    cheapest
    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to Syracuse Bus Stationbus bus
    3. Take the bus from Syracuse Bus Station to Buffalobus bus
    13h 12m
    $74–188

  3. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus Portland / ...
    2. Take the train from Boston to Buffalo Depew Stationtrain train Lake Shore Limited
    15h 55m
    $140–368

  4. Drive 508.3 mi

    1. Drive from Portland, ME to Buffalocar car 508.3 mi
    10h 20m
    $93–134

  5. Bus to Boston Logan Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Portland, ME to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    5h 55m
    $158–957

  6. Fly Portland to Rochester, bus

    1. Fly from Portland (PWM) to Rochester (ROC)plane plane PWM - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    6h 54m
    $298–1,179

  7. Bus to Boston Logan Airport, fly to Rochester, bus

    1. Take the bus from Portland, ME to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane plane BOS - ROC
    3. Take the bus from Rochester Bus Stop to Buffalobus bus
    7h 3m
    $259–823

  8. Bus via New York

    1. Take the bus from Portland, ME to New York, NYbus bus Maine
    2. Take the bus from New York to Buffalobus bus Adt N816 / ...
    15h 20m
    $129–379

  9. Train (Amtrak)

    1. Take the train from Portland to Bostontrain train Downeaster
    2. Take the train from Boston to Buffalo Depew Stationtrain train Lake Shore Limited
    16h 57m
    $143–315

Portland, ME to Buffalo by bus

Calendar12Weekly Buses
Duration13h 12mAverage Duration
Ticket$74Cheapest Price
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Questions & Answers

What companies run services between Portland, ME, USA and Buffalo, NY, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Portland (PWM) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a bus from Portland, ME to Buffalo via Boston, MA - South Station, Boston, and Syracuse Bus Station in around 13h 12m.

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