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How to get fromPortland, ME to Buffaloby plane, bus (Amtrak, Flixbus, Greyhound), bus, train, car, bus (Amtrak) or train (Amtrak)

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There are 8 ways to get from Portland, ME to Buffalo by plane, bus (Amtrak, Flixbus, Greyhound), bus, train, car, bus (Amtrak), or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Portland to Buffalo Niagara International Airport

    best
    1. Fly from Portland (PWM) to Buffalo Niagara International Airport (BUF)plane plane PWM - BUF
    6h 6m
    $224–1,328

  2. Bus via BNIA Driveway & BNIA Terminal

    cheapest
    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston, MA to Syracuse, NYbus bus
    3. Take the bus from Syracuse, NY to Buffalo, NYbus bus
    14h 28m
    $66–203

  3. Bus

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to Syracuse Bus Stationbus bus
    3. Take the bus from Syracuse Bus Station to Buffalobus bus
    13h 21m
    $90–198

  4. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus Portland / ...
    2. Take the train from Boston to Buffalo Depew Stationtrain train Lake Shore Limited
    15h 55m
    $150–568

  5. Drive 508.3 mi

    1. Drive from Portland, ME to Buffalocar car 508.3 mi
    10h 20m
    $93–134

  6. Bus to Boston Logan Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Portland, ME to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    5h 56m
    $177–1,059

  7. Fly Portland to Rochester, bus

    1. Fly from Portland (PWM) to Rochester (ROC)plane plane PWM - ROC
    2. Take the bus from Rochester, NY to Buffalo, NYbus bus
    8h 7m
    $358–1,270

  8. Train (Amtrak)

    1. Take the train from Portland to Bostontrain train Downeaster
    2. Take the train from Boston to Buffalo Depew Stationtrain train Lake Shore Limited
    16h 58m
    $191–455

Portland, ME to Buffalo by bus

Calendar12Weekly Buses
Duration13h 21mAverage Duration
Ticket$90Cheapest Price
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Questions & Answers

What companies run services between Portland, ME, USA and Buffalo, NY, USA?

Delta, Southwest Airlines, and two other airlines fly from Portland (PWM) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a bus from Portland, ME to Buffalo via Boston, MA - South Station, Boston, and Syracuse Bus Station in around 13h 21m.

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