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How to get fromPortland, ME to Buffaloby plane, bus (Amtrak, Greyhound), bus, train, car, or bus (Amtrak, Flixbus)

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There are 7 ways to get from Portland, ME to Buffalo by plane, bus (Amtrak, Greyhound), bus, train, car, or bus (Amtrak, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Portland

    best
    1. Fly from Portland (PWM) to Buffalo Niagara International Airport (BUF)plane plane PWM - BUF
    5h 23m
    $134–736

  2. Bus

    cheapest
    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus Portland / ...
    2. Take the bus from Boston to Buffalobus bus Greyhound US0171
    13h
    $91–183

  3. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus Portland / ...
    2. Take the train from Boston to Buffalo Depew Stationtrain train Lake Shore Limited
    15h 55m
    $183–503

  4. Drive 508.3 mi

    1. Drive from Portland, ME to Buffalocar car 508.3 mi
    10h 20m
    $93–134

  5. Bus to Boston Logan Airport, fly

    1. Take the bus from Portland, ME to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    5h 29m
    $110–608

  6. Bus to Augusta State Airport, fly

    1. Take the bus from Portland Transportation Center to Augusta Transportation Centerbus bus
    2. Fly from Augusta State Airport (AUG) to Buffalo Niagara International Airport (BUF)plane plane AUG - BUF
    7h 9m
    $111–541

  7. Bus via Ithaca

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to Ithacabus bus
    3. Take the bus from Ithaca to Buffalobus bus
    15h 19m
    $104–238

Portland, ME to Buffalo by bus

Calendar7Weekly Buses
Duration13hAverage Duration
Ticket$91Cheapest Price
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Questions & Answers

Map of how to get from Portland, ME to Buffalo.ExpandLaunch map view
  • Distance: 442.5 mi
  • Duration: 5h 23m

What companies run services between Portland, ME, USA and Buffalo, NY, USA?

Southwest Airlines, American Airlines, and three other airlines fly from Portland (PWM) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a bus from Portland, ME to Buffalo via Boston, MA - South Station and Boston in around 13h.

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