The average bus between Pittsburgh and Chicago Loop takes 11h 51m and the fastest bus takes 10h 17m. The bus service runs several times per day from Pittsburgh to Chicago Loop. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Pittsburgh and Chicago Loop. The earliest departure is at 12:55 AM at night, and the last departure from Pittsburgh is at 7:45 PM which arrives into Chicago Loop at 6:41 AM. All services require a transfer at Chicago Bus Station and take an average of 11h 51m. The schedules shown below are for the next available departures.

10h 19m • 1 change
12h 45m • 1 changeArrives next day

11h 41m • 1 change
10h 19m • 1 change
12h 45m • 1 changeArrives next day

11h 41m • 1 change
10h 19m • 1 change
12h 45m • 1 changeArrives next day

11h 38m • 1 changeWant to know about travelling from Pittsburgh to Chicago Loop? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Pittsburgh to Chicago Loop. However, there are services departing from Pittsburgh station and arriving at Chicago Loop station via Chicago Bus Station station. The journey, including transfers, takes approximately 11h 51m.
Pittsburgh to Chicago Loop bus services, operated by Flixbus USA, depart from Pittsburgh Intermodal Station.
Pittsburgh to Chicago Loop bus services, operated by Flixbus USA, arrive at Chicago Bus Station.
The distance between Pittsburgh and Chicago Loop is 658.9 km. The road distance is 771 km.
Greyhound USA operates a bus from Pittsburgh Intermodal Station to Chicago Bus Station twice daily. Tickets cost $75–120 and the journey takes 10h 5m. Flixbus USA also services this route once daily.