The average bus between Pittsburgh and Chicago Loop takes 11h 35m and the fastest bus takes 10h 16m. The bus service runs several times per day from Pittsburgh to Chicago Loop. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Pittsburgh and Chicago Loop. The earliest departure is at 12:55 AM at night, and the last departure from Pittsburgh is at 7:45 PM which arrives into Chicago Loop at 6:39 AM. All services require a transfer at Chicago Bus Station and take an average of 11h 35m. The schedules shown below are for the next available departures.

9h 21m • 1 change

11h 46m • 1 change
Arrives next day

10h 41m • 1 change

9h 21m • 1 change

11h 46m • 1 change
Arrives next day

10h 41m • 1 change

9h 21m • 1 change

11h 46m • 1 change
Arrives next day

10h 41m • 1 change

9h 21m • 1 change

11h 46m • 1 change
Arrives next day

10h 35m • 1 change
Want to know about travelling from Pittsburgh to Chicago Loop? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Pittsburgh to Chicago Loop. However, there are services departing from Pittsburgh station and arriving at Chicago Loop station via Chicago Bus Station station. The journey, including transfers, takes approximately 11h 35m.
Pittsburgh to Chicago Loop bus services, operated by Greyhound USA, depart from Pittsburgh Intermodal Station.
Pittsburgh to Chicago Loop bus services, operated by Greyhound USA, arrive at Chicago Bus Station.
The distance between Pittsburgh and Chicago Loop is 658.9 km. The road distance is 771 km.
Greyhound USA operates a bus from Pittsburgh Intermodal Station to Chicago Bus Station twice daily. Tickets cost $80–160 and the journey takes 10h 5m. Flixbus USA also services this route once daily.