The average bus between Pisa and Palermo takes 23h 3m and the fastest bus takes 22h 5m. The bus service runs several times per day from Pisa to Palermo. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Pisa and Palermo. The earliest departure is at 4:45 AM at night, and the last departure from Pisa is at 5:10 PM which arrives into Palermo at 3:15 PM. All services require a transfer, and take on average 23h 3m. The schedules shown below are for the next available departures.
Arrives next day

23h • 1 change
Arrives next day

22h 5m • 1 change
Arrives next day

23h • 1 change
Arrives next day

22h 5m • 1 change
Want to know about travelling from Pisa to Palermo? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Pisa to Palermo. However, there are services departing from Pisa station and arriving at Palermo station via Florence Villa Constanza Bus Station station. The journey, including transfers, takes approximately 23h 3m.
Pisa to Palermo bus services, operated by FlixBus, depart from Pisa station.
Pisa to Palermo bus services, operated by FlixBus, arrive at Palermo station.
Book your Pisa to Palermo bus tickets online with FlixBus.
The distance between Pisa and Palermo is 667.1 km. The road distance is 1,326 km.
You can take a bus from Pisa to Palermo via Florence Villa Constanza Bus Station in around 19h.