The average bus between Palermo and Pisa takes 22h 20m and the fastest bus takes 20h 55m. The bus service runs several times per day from Palermo to Pisa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Palermo and Pisa. The earliest departure is at 3:25 PM in the afternoon, and the last departure from Palermo is at 9:10 PM which arrives into Pisa at 6:05 PM. All services require a transfer, and take on average 22h 20m. The schedules shown below are for the next available departures.
Arrives next day

22h 25m • 1 change
Arrives next day

20h 55m • 1 change
Arrives next day

22h 25m • 1 change
Arrives next day

20h 55m • 1 change
Arrives next day

22h 25m • 1 change
Arrives next day

20h 55m • 1 change
Want to know about travelling from Palermo to Pisa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Palermo to Pisa. However, there are services departing from Palermo station and arriving at Pisa station via Florence Villa Constanza Bus Station station. The journey, including transfers, takes approximately 22h 20m.
Palermo to Pisa bus services, operated by FlixBus, depart from Palermo station.
Palermo to Pisa bus services, operated by FlixBus, arrive at Pisa station.
Book your Palermo to Pisa bus tickets online with FlixBus.
The distance between Palermo and Pisa is 667.1 km. The road distance is 1,351 km.
You can take a bus from Palermo to Pisa via Florence Villa Constanza Bus Station in around 19h 25m.