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Myrtle Beach to Gainesville buses

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Trip Overview

The bus between Myrtle Beach and Gainesville takes 47h 19m. The bus runs, on average, 4 times per week from Myrtle Beach to Gainesville. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

47h 19m
Duration
519 mi
Distance
$108
Average price
4 times a week
Frequency

Myrtle Beach to Gainesville bus times

Buses run 4 times a week between Myrtle Beach and Gainesville. The service departs Myrtle Beach at 12:40 PM in the afternoon, which arrives into Gainesville at 11:59:00. All services require a transfer at Camden and take an average of 47h 19m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

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    Arrives +2 days

    Greyhound USAGreyhound USAFlixbus USA47h 19m • 2 changes

Departing Wednesday, November 11, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAFlixbus USA47h 19m • 2 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAFlixbus USA47h 19m • 2 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAFlixbus USA47h 19m • 2 changes

Frequently asked questions

Want to know about travelling from Myrtle Beach to Gainesville? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Myrtle Beach to Gainesville.ExpandLaunch map view
  • Distance: 518.9 mi
  • Duration: 47h 19m

What companies run services between Myrtle Beach, SC, USA and Gainesville, FL, USA?

You can take a bus from Myrtle Beach Bus Station to Gainesville via Camden and Jacksonville in around 14h 14m.

Operators