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How to get fromMyrtle Beach to Gainesvilleby plane, bus (Greyhound, Flixbus), bus, train or car

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There are 6 ways to get from Myrtle Beach to Gainesville by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Gainesville Regional Airport

    best
    1. Fly from Myrtle Beach (MYR) to Gainesville Regional Airport (GNV)plane plane MYR - GNV
    5h 18m
    $67–364

  2. Bus

    1. Take the bus from Myrtle Beach, SC to Florencebus bus
    2. Take the bus from Florence Bus Station to Jacksonvillebus bus
    3. Take the bus from Jacksonville to Gainesvillebus bus
    10h 25m
    $92–186

  3. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Jacksonvilletrain train
    3. Take the bus from Jacksonville to Gainesvillebus bus
    11h 17m
    $79–128

  4. Drive 395.2 mi

    1. Drive from Myrtle Beach to Gainesvillecar car 395.2 mi
    7h 33m
    $73–105

  5. Fly to Orlando, bus

    1. Fly from Myrtle Beach (MYR) to Orlando (MCO)plane plane MYR - MCO
    2. Take the bus from Orlando RedCoach Station to Gainesvillebus bus
    5h
    $114–434

  6. Fly to Jacksonville, bus

    1. Fly from Myrtle Beach (MYR) to Jacksonville (JAX)plane plane MYR - JAX
    2. Take the bus from Jacksonville to Gainesvillebus bus
    7h 40m
    $267–837

Myrtle Beach to Gainesville by bus

Calendar6Weekly Buses
Duration10h 25mAverage Duration
Ticket$92Cheapest Price
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Questions & Answers

What companies run services between Myrtle Beach, SC, USA and Gainesville, FL, USA?

Delta and American Airlines fly from Myrtle Beach (MYR) to Gainesville Regional Airport (GNV) every 4 hours. Alternatively, you can take a bus from Myrtle Beach, SC to Gainesville via Florence, Florence Bus Station, and Jacksonville in around 10h 25m.

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