Rome2Rio

Mesa to Chicago buses

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Trip Overview

The average bus between Mesa and Chicago takes 2d 20h and the fastest bus takes 2d 18h. The bus runs, on average, 4 times per week from Mesa to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d 20h
Duration
2,155 mi
Distance
$458
Average price
4 times a week
Frequency

Mesa to Chicago bus times

Buses run 4 times a week between Mesa and Chicago. The earliest departure is at 12:59 PM in the afternoon, and the last departure from Mesa is at 9:04 PM which arrives into Chicago at 4:25 PM. All services require a transfer at University Dr & Rural Rd and take an average of 2d 20h. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

  •  → 

    Arrives +3 days

    Valley MetroFlixbus USAGreyhound USAGreyhound USAGreyhound USA3d 2h • 4 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives +3 days

    Valley MetroFlixbus USAGreyhound USAGreyhound USAGreyhound USA2d 18h • 4 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +3 days

    Valley MetroFlixbus USAGreyhound USAGreyhound USAGreyhound USA2d 18h • 4 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +3 days

    Valley MetroFlixbus USAGreyhound USAGreyhound USAGreyhound USA2d 18h • 4 changes

Frequently asked questions

Want to know about travelling from Mesa to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Mesa to Chicago.ExpandLaunch map view
  • Distance: 2,155.1 mi
  • Duration: 2d 20h

What companies run services between Mesa, AZ, USA and Chicago, IL, USA?

You can take a bus from University Dr & Mesa Dr to Chicago Bus Station via University Dr & Rural Rd, Tempe, Phoenix Sky Harbor Airport/44th Street Sky Train Station, El Paso Bus Station, and Denver Union Station in around 47h 3m.

Operators