The bus between Mayo Clinic and Appleton takes 6h 15m. There is at least one bus per day from Mayo Clinic to Appleton. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Mayo Clinic and Appleton. The earliest departure is at 12:55 PM in the afternoon, and the last departure from Mayo Clinic is at 12:55 PM which arrives into Appleton at 7:10 PM. All services require a transfer at Rochester and take an average of 6h 15m. The schedules shown below are for the next available departures.
Want to know about travelling from Mayo Clinic to Appleton? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Mayo Clinic to Appleton. However, there are services departing from Mayo Clinic station and arriving at Appleton station via La Crosse. The journey, including transfers, takes approximately 6h 15m.
Mayo Clinic to Appleton bus services, operated by Jefferson Lines, depart from Rochester station.
Mayo Clinic to Appleton bus services, operated by Jefferson Lines, arrive at Appleton Valley Transit station.
The distance between Mayo Clinic and Appleton is 324.3 km. The road distance is 415 km.
You can take a vehicle from Mayo Clinic to Appleton Valley Transit via Rochester, La Crosse, and La Crosse Grand River Station in around 7h 18m.
