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How to get fromMayo Clinic to Appletonby plane, bus, taxi or car

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There are 8 ways to get from Mayo Clinic to Appleton by plane, bus, taxi, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Rochester to Appleton International Airport

    best
    1. Fly from Rochester (RST) to Appleton International Airport (ATW)plane plane RST - ATW
    5h 21m
    $65–370

  2. Drive 233.6 mi

    cheapest
    1. Drive from Mayo Clinic to Appletoncar car 233.6 mi
    4h 31m
    $43–62

  3. Bus, taxi

    1. Take the bus from Rochester to St. Paulbus bus
    2. Take the bus from St. Paul-Minneapolis to Green Bay Amtrak Stationbus bus
    3. Take the taxi from Green Bay Amtrak Station to Appletontaxi taxi
    9h 4m

  4. Fly Rochester to Green Bay, taxi

    1. Fly from Rochester (RST) to Green Bay (GRB)plane plane RST - GRB
    2. Take the taxi from Green Bay (GRB) to Appletontaxi taxi
    5h 55m
    $146–467

  5. Bus to Minneapolis–Saint Paul International Airport, fly to Appleton International Airport

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Appleton International Airport (ATW)plane plane MSP - ATW
    3h 55m
    $88–422

  6. Bus to Minneapolis–Saint Paul International Airport, fly to Green Bay, taxi

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Green Bay (GRB)plane plane MSP - GRB
    3. Take the taxi from Green Bay (GRB) to Appletontaxi taxi
    4h 19m
    $174–519

  7. Bus to Minneapolis–Saint Paul International Airport, fly to Central Wisconsin Airport, drive

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Central Wisconsin Airport (CWA)plane plane MSP - CWA
    3. Drive from Central Wisconsin Airport (CWA) to Appletoncar car
    5h 16m
    $79–402

  8. Bus, taxi via Madison

    1. Take the bus from Rochester to Madisonbus bus
    2. Take the bus from Madison to Green Bay Transit, WIbus bus 106
    3. Take the taxi from Green Bay Transit, WI to Appletontaxi taxi
    10h 4m
    $170–338

Rochester (RST) to Appleton International Airport (ATW) flights

Calendar61Weekly Planes
Duration5h 1mAverage Duration
Ticket$46Cheapest Price
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Questions & Answers

What companies run services between Mayo Clinic, MN, USA and Appleton, WI, USA?

American Airlines, Delta, and United Airlines fly from Rochester (RST) to Appleton International Airport (ATW) every 3 hours.

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