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How to get fromMayo Clinic to Appletonby bus, car or plane

Find Transport to Appleton

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There are 6 ways to get from Mayo Clinic to Appleton by bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Rochester to La Crossebus bus Jefferson 965
    2. Take the bus from La Crosse Grand River Station to Appleton Valley Transitbus bus La Crosse
    7h 18m
    $41–92

  2. Drive 233.6 mi

    1. Drive from Mayo Clinic to Appletoncar car 233.6 mi
    4h 31m
    $43–62

  3. Fly Rochester to Appleton International Airport

    1. Fly from Rochester (RST) to Appleton International Airport (ATW)plane plane RST - ATW
    5h 32m
    $65–360

  4. Bus to Minneapolis–Saint Paul International Airport, fly to Appleton International Airport

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Appleton International Airport (ATW)plane plane MSP - ATW
    3h 47m
    $119–443

  5. Fly Rochester to Green Bay

    1. Fly from Rochester (RST) to Green Bay (GRB)plane plane RST - GRB
    6h 26m
    $81–390

  6. Bus to Minneapolis–Saint Paul International Airport, fly to Green Bay

    1. Take the bus from Groome Transportation Office - Rochester to Minneapolis / St Paul Airportbus bus
    2. Fly from Minneapolis–Saint Paul International Airport (MSP) to Green Bay (GRB)plane plane MSP - GRB
    5h 15m
    $135–463

Mayo Clinic to Appleton by foot and bus

Calendar7Weekly Services
Duration7h 18mAverage Duration
Ticket$41Cheapest Price
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Questions & Answers

What companies run services between Mayo Clinic, MN, USA and Appleton, WI, USA?

You can take a vehicle from Mayo Clinic to Appleton Valley Transit via Rochester, La Crosse, and La Crosse Grand River Station in around 7h 18m. Alternatively, Delta, United Airlines, and American Airlines fly from Rochester (RST) to Appleton International Airport (ATW) every 4 hours.

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